Detailed Information on Publication Record
2023
Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor
RAFČÍKOVÁ, Julie, Marie NOVÁKOVÁ and Tibor STRAČINABasic information
Original name
Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor
Authors
RAFČÍKOVÁ, Julie (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Tibor STRAČINA (703 Slovakia, belonging to the institution)
Edition
Physiological research, Praha, Fyziologický ústav AV ČR, 2023, 0862-8408
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.100 in 2022
RIV identification code
RIV/00216224:14110/23:00131540
Organization unit
Faculty of Medicine
UT WoS
001049127500003
Keywords in English
Schizophrenia; Cardiovascular diseases; Sigma 1 receptor
Tags
International impact, Reviewed
Změněno: 30/8/2023 13:38, Mgr. Tereza Miškechová
Abstract
V originále
Contemporary society is characterized by rapid changes. Various epidemiological, political and economic crises represent a burden to mental health of nowadays population, which may at least partially explain the increasing incidence of mental disorders, including schizophrenia. Schizophrenia is associated with premature mortality by at least 13-15 years. The leading cause of premature mortality in schizophrenia patients is high incidence of cardiovascular diseases. The specific-cause mortality risk for cardiovascular diseases in schizophrenia patients is more than twice higher as compared to the general population. Several factors are discussed as the factor of cardiovascular diseases development. Intensive efforts to identify possible link between schizophrenia and cardiovascular diseases are made. It seems that sigma 1 receptor may represent such link. By modulation of the activity of several neurotransmitter systems, including dopamine, glutamate, and GABA, sigma 1 receptor might play a role in pathophysiology of schizophrenia. Moreover, significant roles of sigma 1 receptor in cardiovascular system have been repeatedly reported. The detailed role of sigma 1 receptor in both schizophrenia and cardiovascular disorders development however remains unclear. The article presents an overview of current knowledge about the association between schizophrenia and cardiovascular diseases and proposes possible explanations with special emphasis on the role of the sigma 1 receptor.
Links
| MUNI/A/1343/2022, interní kód MU |
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