| ÇELIKER, Canan, Kamila WEISSOVÁ, Kateřina AMRUZ ČERNÁ, Jan OPPELT, Birthe DORGAU, Francisco MOLINA GAMBIN, Jana ŠEBESTÍKOVÁ, Majlinda LAKO, Evelyne SERNAGOR, Petra LISKOVA and Tomáš BÁRTA. Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light. iSCIENCE. CAMBRIDGE: CELL PRESS, 2023, vol. 26, No 7, p. 1-20. ISSN 2589-0042. Available from: https://dx.doi.org/10.1016/j.isci.2023.107237. |
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@article{2306618,
author = {Çeliker, Canan and Weissová, Kamila and Amruz Černá, Kateřina and Oppelt, Jan and Dorgau, Birthe and Molina Gambin, Francisco and Šebestíková, Jana and Lako, Majlinda and Sernagor, Evelyne and Liskova, Petra and Bárta, Tomáš},
article_location = {CAMBRIDGE},
article_number = {7},
doi = {http://dx.doi.org/10.1016/j.isci.2023.107237},
keywords = {Light-responsive microRNA molecules; human retinal organoids},
language = {eng},
issn = {2589-0042},
journal = {iSCIENCE},
title = {Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light},
url = {https://www.sciencedirect.com/science/article/pii/S2589004223013147?via%3Dihub},
volume = {26},
year = {2023}
}
TY - JOUR
ID - 2306618
AU - Çeliker, Canan - Weissová, Kamila - Amruz Černá, Kateřina - Oppelt, Jan - Dorgau, Birthe - Molina Gambin, Francisco - Šebestíková, Jana - Lako, Majlinda - Sernagor, Evelyne - Liskova, Petra - Bárta, Tomáš
PY - 2023
TI - Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light
JF - iSCIENCE
VL - 26
IS - 7
SP - 1-20
EP - 1-20
PB - CELL PRESS
SN - 25890042
KW - Light-responsive microRNA molecules
KW - human retinal organoids
UR - https://www.sciencedirect.com/science/article/pii/S2589004223013147?via%3Dihub
N2 - Cells in the human retina must rapidly adapt to constantly changing visual stimuli. This fast adaptation to varying levels and wavelengths of light helps to regulate circadian rhythms and allows for adaptation to high levels of illumination, thereby enabling the rest of the visual system to remain responsive. It has been shown that retinal microRNA (miRNA) molecules play a key role in regulating these processes. However, despite extensive research using various model organisms, light-regulated miRNAs in human retinal cells remain unknown. Here, we aim to characterize these miRNAs. We generated light-responsive human retinal organoids that express miRNA families and clusters typically found in the retina. Using an in-house developed photostimulation device, we identified a subset of light regulated miRNAs. Importantly, we found that these miRNAs are differentially regulated by distinct wavelengths of light and have a rapid turnover, highlighting the dynamic and adaptive nature of the human retina.
ER -
$\backslash$C CELIKER, Canan, Kamila WEISSOVÁ, Kateřina AMRUZ ČERNÁ, Jan OPPELT, Birthe DORGAU, Francisco MOLINA GAMBIN, Jana ŠEBESTÍKOVÁ, Majlinda LAKO, Evelyne SERNAGOR, Petra LISKOVA and Tomáš BÁRTA. Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light. \textit{iSCIENCE}. CAMBRIDGE: CELL PRESS, 2023, vol.~26, No~7, p.~1-20. ISSN~2589-0042. Available from: https://dx.doi.org/10.1016/j.isci.2023.107237.
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