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@proceedings{2307817,
author = {Souralová, Tereza and Hulínová, Daniela and Ješeta, Michal and Ventruba, Pavel and Hampl, Aleš and Koutná, Irena},
booktitle = {ISSCR Annual meeting 2023, Boston, USA},
keywords = {human embryonic stem cells; Vitronectin},
language = {eng},
title = {Vitronectin is a xeno-free and defined surface for the derivation of human embryonic stem cells},
year = {2023}
}
TY - CONF
ID - 2307817
AU - Souralová, Tereza - Hulínová, Daniela - Ješeta, Michal - Ventruba, Pavel - Hampl, Aleš - Koutná, Irena
PY - 2023
TI - Vitronectin is a xeno-free and defined surface for the derivation of human embryonic stem cells
KW - human embryonic stem cells
KW - Vitronectin
N2 - Human embryonic stem cells (hESCs) have unique abilities that enable their use in cell therapy, diseasemodelling, and drug development. Their derivation is usually performed using a feeder layer, which isundefined and potentially contagious, and because of these difficulties, there is a tendency to replacefeeders with xeno-free defined substrates in recent years. We used truncated vitronectin for thederivation of hESCs for the first time, derived three hESC lines, and confirmed their undifferentiatedstate, hESC morphology, and standard karyotypes together with their potential to differentiate into three germ layers. These results support the conclusion that truncated vitronectin is a defined xeno-freesubstrate that is suitable for the derivation of hESCs.
ER -
SOURALOVÁ, Tereza, Daniela HULÍNOVÁ, Michal JEŠETA, Pavel VENTRUBA, Aleš HAMPL and Irena KOUTNÁ. Vitronectin is a xeno-free and defined surface for the derivation of human embryonic stem cells. In \textit{ISSCR Annual meeting 2023, Boston, USA}. 2023.
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