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@article{2308505, author = {Fňašková, Monika and Říha, Pavel and Nečasová, Markéta and Preiss, Marek and Rektor, Ivan}, article_location = {London}, article_number = {1}, doi = {http://dx.doi.org/10.1038/s41598-023-40618-3}, keywords = {GRAY-MATTER; BRAIN; DISORDER; CONSEQUENCES; VOLUME; FEAR; CINGULATE; VERSION; IMPACT; CZECH}, language = {eng}, issn = {2045-2322}, journal = {Nature Scientific Reports}, title = {Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors.}, url = {https://www.nature.com/articles/s41598-023-40618-3}, volume = {13}, year = {2023} }
TY - JOUR ID - 2308505 AU - Fňašková, Monika - Říha, Pavel - Nečasová, Markéta - Preiss, Marek - Rektor, Ivan PY - 2023 TI - Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors. JF - Nature Scientific Reports VL - 13 IS - 1 SP - 1-9 EP - 1-9 PB - NATURE RESEARCH SN - 20452322 KW - GRAY-MATTER KW - BRAIN KW - DISORDER KW - CONSEQUENCES KW - VOLUME KW - FEAR KW - CINGULATE KW - VERSION KW - IMPACT KW - CZECH UR - https://www.nature.com/articles/s41598-023-40618-3 N2 - This study focuses on hippocampal and amygdala volume, seed-based connectivity, and psychological traits of Holocaust survivors who experienced stress during prenatal and early postnatal development. We investigated people who lived in Central Europe during the Holocaust and who, as Jews, were in imminent danger. The group who experienced stress during their prenatal development and early postnatal (PreP) period (n=11) were compared with a group who experienced Holocaust-related stress later in their lives: in late childhood, adolescence, and early adulthood (ChA) (n=21). The results of volumetry analysis showed significantly lower volumes of both hippocampi and the right amygdala in the PreP group. Seed-based connectivity analysis revealed increased connectivity from the seed in the right amygdala to the middle and posterior cingulate cortex, caudate, and inferior left frontal operculum in the PreP group. Psychological testing found higher levels of traumatic stress symptoms (TCS-40) and lower levels of well-being (SOS-10) in the PreP group than in the ChA group. The results of our study demonstrate that extreme stress experienced during prenatal and early postnatal life has a profound lifelong impact on the hippocampus and amygdala and on several psychological characteristics. ER -
FŇAŠKOVÁ, Monika, Pavel ŘÍHA, Markéta NEČASOVÁ, Marek PREISS and Ivan REKTOR. Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2023, vol.~13, No~1, p.~1-9. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-023-40618-3.
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