J 2023

Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors.

FŇAŠKOVÁ, Monika, Pavel ŘÍHA, Markéta NEČASOVÁ, Marek PREISS, Ivan REKTOR et. al.

Basic information

Original name

Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors.

Authors

FŇAŠKOVÁ, Monika (203 Czech Republic, belonging to the institution), Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Markéta NEČASOVÁ (203 Czech Republic, belonging to the institution), Marek PREISS (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Nature Scientific Reports, London, NATURE RESEARCH, 2023, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.600 in 2022

RIV identification code

RIV/00216224:14740/23:00131640

Organization unit

Central European Institute of Technology

DOI

UT WoS

001113423900027

Keywords in English

GRAY-MATTER; BRAIN; DISORDER; CONSEQUENCES; VOLUME; FEAR; CINGULATE; VERSION; IMPACT; CZECH

Tags

Tags

International impact, Reviewed
Změněno: 10/10/2024 13:20, Ing. Jana Kuchtová

Abstract

V originále

This study focuses on hippocampal and amygdala volume, seed-based connectivity, and psychological traits of Holocaust survivors who experienced stress during prenatal and early postnatal development. We investigated people who lived in Central Europe during the Holocaust and who, as Jews, were in imminent danger. The group who experienced stress during their prenatal development and early postnatal (PreP) period (n=11) were compared with a group who experienced Holocaust-related stress later in their lives: in late childhood, adolescence, and early adulthood (ChA) (n=21). The results of volumetry analysis showed significantly lower volumes of both hippocampi and the right amygdala in the PreP group. Seed-based connectivity analysis revealed increased connectivity from the seed in the right amygdala to the middle and posterior cingulate cortex, caudate, and inferior left frontal operculum in the PreP group. Psychological testing found higher levels of traumatic stress symptoms (TCS-40) and lower levels of well-being (SOS-10) in the PreP group than in the ChA group. The results of our study demonstrate that extreme stress experienced during prenatal and early postnatal life has a profound lifelong impact on the hippocampus and amygdala and on several psychological characteristics.

Links

NV18-04-00559, research and development project
Name: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků
Investor: Ministry of Health of the CR, Neurobiological and psychological markers of reaction to extreme stress and its impact on offspring - three generation study of holocaust survivors and their offspring
90062, large research infrastructures
Name: Czech-BioImaging
90250, large research infrastructures
Name: Czech-BioImaging III