Bright photon upconversion in LiYbF4:Tm3+@LiYF4 nanoparticles
and their application for singlet oxygen generation and in
immunoassay for SARS-CoV-2 nucleoprotein

J 2023

Bright photon upconversion in LiYbF4:Tm3+@LiYF4 nanoparticles and their application for singlet oxygen generation and in immunoassay for SARS-CoV-2 nucleoprotein

DROZDOWSKI, Adrian, Natalia JURGA, Dominika PRZYBYLSKA, Julian BRANDMEIER, Zdeněk FARKA et. al.

Basic information

Original name

Bright photon upconversion in LiYbF4:Tm3+@LiYF4 nanoparticles and their application for singlet oxygen generation and in immunoassay for SARS-CoV-2 nucleoprotein

Authors

DROZDOWSKI, Adrian (616 Poland), Natalia JURGA (616 Poland), Dominika PRZYBYLSKA, Julian BRANDMEIER (276 Germany, belonging to the institution), Zdeněk FARKA (203 Czech Republic, guarantor, belonging to the institution), Hans-Heiner GORRIS (276 Germany, belonging to the institution) and Tomasz GRZYB (616 Poland)

Edition

Journal of Colloid and Interface Science, Elsevier, 2023, 0021-9797

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10406 Analytical chemistry

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 9.900 in 2022

RIV identification code

RIV/00216224:14310/23:00134230

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.jcis.2023.06.034

UT WoS

001025157500001

Keywords in English

NIR to UV upconverting nanoparticles; Singlet oxygen; Reactive oxygen species; Covid-19 diagnosis

Abstract

V originále

Photon upconversion is an intensively investigated phenomenon in the materials sciences due to its unique applications, mainly in biomedicine for disease prevention and treatment. This study reports the synthesis and properties of tetragonal LiYbF4:Tm3+@LiYF4 core@shell nanoparticles (NPs) and their applications. The NPs had sizes ranging from 18.5 to 23.7 nm. As a result of the energy transfer between Yb3+ and Tm3+ ions, the synthesized NPs show intense emission in the ultraviolet (UV) range up to 347 nm under 975 nm excitation. The bright emission in the UV range allows for singlet oxygen generation in the presence of hematoporphyrin on the surface of NPs. Our studies show that irradiation with a 975 nm laser of the functionalized NPs allows for the production of amounts of singlet oxygen easily detectable by Singlet Oxygen Sensor Green. The high emission intensity of NPs at 800 nm allowed the application of the synthesized NPs in an upconversion-linked immunosorbent assay (ULISA) for highly sensitive detection of the nucleoprotein from SARS-CoV-2, the causative agent of Covid-19. This article proves that LiYbF4:Tm3+@LiYF4 core@shell nanoparticles can be perfect alternatives for the most commonly studied upconverting NPs based on the NaYF4 host compound and are good candidates for biomedical applications.

Links

GA21-03156S, research and development project

Name: Foton-upkonverzní značky pro mikrofluidní jednomolekulové imunostanovení proteinových biomarkerů

Investor: Czech Science Foundation

Citovat

DROZDOWSKI, Adrian, Natalia JURGA, Dominika PRZYBYLSKA, Julian BRANDMEIER, Zdeněk FARKA, Hans-Heiner GORRIS and Tomasz GRZYB. Bright photon upconversion in LiYbF4:Tm3+@LiYF4 nanoparticles and their application for singlet oxygen generation and in immunoassay for SARS-CoV-2 nucleoprotein. Journal of Colloid and Interface Science. Elsevier, 2023, vol. 649, November 2023, p. 49-57. ISSN 0021-9797. Available from: https://dx.doi.org/10.1016/j.jcis.2023.06.034.

@article{2311258,
   author = {Drozdowski, Adrian and Jurga, Natalia and Przybylska, Dominika and Brandmeier, Julian and Farka, Zdeněk and Gorris, HansandHeiner and Grzyb, Tomasz},
   article_number = {November 2023},
   doi = {http://dx.doi.org/10.1016/j.jcis.2023.06.034},
   keywords = {NIR to UV upconverting nanoparticles; Singlet oxygen; Reactive oxygen species; Covid-19 diagnosis},
   language = {eng},
   issn = {0021-9797},
   journal = {Journal of Colloid and Interface Science},
   title = {Bright photon upconversion in LiYbF4:Tm3+@LiYF4 nanoparticles and their application for singlet oxygen generation and in immunoassay for SARS-CoV-2 nucleoprotein},
   url = {https://www.sciencedirect.com/science/article/pii/S0021979723010573},
   volume = {649},
   year = {2023}
}

TY  - JOUR
ID  - 2311258
AU  - Drozdowski, Adrian - Jurga, Natalia - Przybylska, Dominika - Brandmeier, Julian - Farka, Zdeněk - Gorris, Hans-Heiner - Grzyb, Tomasz
PY  - 2023
TI  - Bright photon upconversion in LiYbF4:Tm3+@LiYF4 nanoparticles and their application for singlet oxygen generation and in immunoassay for SARS-CoV-2 nucleoprotein
JF  - Journal of Colloid and Interface Science
VL  - 649
IS  - November 2023
SP  - 49-57
EP  - 49-57
PB  - Elsevier
SN  - 00219797
KW  - NIR to UV upconverting nanoparticles
KW  - Singlet oxygen
KW  - Reactive oxygen species
KW  - Covid-19 diagnosis
UR  - https://www.sciencedirect.com/science/article/pii/S0021979723010573
N2  - Photon upconversion is an intensively investigated phenomenon in the materials sciences due to its unique applications, mainly in biomedicine for disease prevention and treatment. This study reports the synthesis and properties of tetragonal LiYbF4:Tm3+@LiYF4 core@shell nanoparticles (NPs) and their applications. The NPs had sizes ranging from 18.5 to 23.7 nm. As a result of the energy transfer between Yb3+ and Tm3+ ions, the synthesized NPs show intense emission in the ultraviolet (UV) range up to 347 nm under 975 nm excitation. The bright emission in the UV range allows for singlet oxygen generation in the presence of hematoporphyrin on the surface of NPs. Our studies show that irradiation with a 975 nm laser of the functionalized NPs allows for the production of amounts of singlet oxygen easily detectable by Singlet Oxygen Sensor Green. The high emission intensity of NPs at 800 nm allowed the application of the synthesized NPs in an upconversion-linked immunosorbent assay (ULISA) for highly sensitive detection of the nucleoprotein from SARS-CoV-2, the causative agent of Covid-19. This article proves that LiYbF4:Tm3+@LiYF4 core@shell nanoparticles can be perfect alternatives for the most commonly studied upconverting NPs based on the NaYF4 host compound and are good candidates for biomedical applications.
ER  -

DROZDOWSKI, Adrian, Natalia JURGA, Dominika PRZYBYLSKA, Julian BRANDMEIER, Zdeněk FARKA, Hans-Heiner GORRIS and Tomasz GRZYB. Bright photon upconversion in LiYbF4:Tm3+@LiYF4 nanoparticles and their application for singlet oxygen generation and in immunoassay for SARS-CoV-2 nucleoprotein. \textit{Journal of Colloid and Interface Science}. Elsevier, 2023, vol.~649, November 2023, p.~49-57. ISSN~0021-9797. Available from: https://dx.doi.org/10.1016/j.jcis.2023.06.034.

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