J 2023

Benzo[b]naphtho[d]thiophenes and naphthylbenzo[b]thiophenes: Their aryl hydrocarbon receptor-mediated activities and environmental presence

MARVANOVÁ, Soňa; Kateřina PĚNČÍKOVÁ; Lenka PÁLKOVÁ; Miroslav CIGANEK; Jiří PETRÁŠ et. al.

Základní údaje

Originální název

Benzo[b]naphtho[d]thiophenes and naphthylbenzo[b]thiophenes: Their aryl hydrocarbon receptor-mediated activities and environmental presence

Autoři

MARVANOVÁ, Soňa (203 Česká republika); Kateřina PĚNČÍKOVÁ (203 Česká republika); Lenka PÁLKOVÁ (203 Česká republika, domácí); Miroslav CIGANEK (203 Česká republika); Jiří PETRÁŠ (203 Česká republika, domácí); Anna LNĚNIČKOVÁ (203 Česká republika, domácí); Jan VONDRÁČEK (203 Česká republika) a Miroslav MACHALA (203 Česká republika, garant)

Vydání

Science of The Total Environment, Elsevier, 2023, 0048-9697

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 8.200

Kód RIV

RIV/00216224:14310/23:00131710

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000971841500001

EID Scopus

2-s2.0-85151452923

Klíčová slova anglicky

AhR activity; Airborne particulate matter; Freshwater sediments; Gap junctional intercellular communication; Polycyclic aromatic sulfur heterocyclic compounds

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 5. 3. 2024 11:00, Mgr. Eva Dubská

Anotace

V originále

Polycyclic aromatic sulfur heterocyclic compounds (PASHs) belong among ubiquitous environmental pollutants; however, their toxic effects remain poorly understood. Here, we studied the aryl hydrocarbon receptor (AhR)-mediated activity of dibenzothiophene, benzo[b]naphtho[d]thiophenes, and naphthylbenzo[b]thiophenes, as well as their presence in two types of environmental matrices: river sediments collected from both rural and urban areas, and in airborne particulate matter (PM2.5) sampled in cities with different levels and sources of pollution. Benzo[b]naphtho[2,1-d]thiophene, benzo[b]naphtho[2,3-d]thiophene, 2,2-naphthylbenzo[b]thiophene, and 2,1-naphthylbenzo[b]thiophene were newly identified as efficient AhR agonists in both rat and human AhR-based reporter gene assays, with 2,2-naphthylbenzo[b]thiophene being the most potent compound identified in both species. Benzo[b]naphtho[1,2-d]thiophene and 3,2-naphthylbenzo[b]thiophene elicited AhR-mediated activity only in the rat liver cell model, while dibenzothiophene and 3,1-naphthylbenzo[b]thiophene were inactive in either cell type. Independently of their ability to activate the AhR, benzo[b]naphtho[1,2-d]thiophene, 2,1-naphthylbenzo[b]thiophene, 3,1-naphthylbenzo[b]thiophene, and 3,2-naphthylbenzo[b]thiophene inhibited gap junctional intercellular communication in a model of rat liver epithelial cells. Benzo[b]naphtho[d]thiophenes were dominant PASHs present in both PM2.5 and sediment samples, with benzo[b]naphtho[2,1-d]thiophene being the most abundant one, followed by benzo[b]naphtho[2,3-d]thiophene. The levels of naphthylbenzo[b]thiophenes were mostly low or below detection limit. Benzo[b]naphtho[2,1-d]thiophene and benzo[b]naphtho[2,3-d]thiophene were identified as the most significant contributors to the AhR-mediated activity in the environmental samples evaluated in this study. Both induced nuclear translocation of the AhR, and they induced CYP1A1 expression in a time-dependent manner, suggesting that their AhR-mediated activity may depend on the rate of their intracellular metabolism. In conclusion, some PASHs could be significant contributors to the overall AhR-mediated toxicity of complex environmental samples suggesting that more attention should be paid to the potential health impacts of this group of environmental pollutants.