Prospective analysis of febrile neutropenia patients with
bacteraemia: the results of an international ID-IRI study

J 2023

Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study

ERDEM, Hakan, Esra KOCOGLU, Handan ANKARALI, Rehab EL-SOKKARY, Atousa HAKAMIFARD et. al.

Basic information

Original name

Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study

Authors

ERDEM, Hakan (792 Turkey, guarantor), Esra KOCOGLU (792 Turkey), Handan ANKARALI (792 Turkey), Rehab EL-SOKKARY (818 Egypt), Atousa HAKAMIFARD (364 Islamic Republic of Iran), Ridvan KARAALI (792 Turkey), Sholpan KULZHANOVA (398 Kazakhstan), Amani EL-KHOLY (818 Egypt), Hamed Azhdari TEHRANI (364 Islamic Republic of Iran), Reham KHEDR (818 Egypt), Ayse KAYA-KALEM (792 Turkey), Nenad PANDAK (512 Oman), Meliha CAGLA-SONMEZER (792 Turkey), Summiya NIZAMUDDIN (586 Pakistan), Hande BERK-CAM (792 Turkey), Rahmet GUNER (792 Turkey), Jehan Ali ELKHOLY (818 Egypt), Ferran LLOPIS (724 Spain), Andrea MARINO (380 Italy), Roman STEBEL (203 Czech Republic, belonging to the institution), Balint Gergely SZABO (348 Hungary), Maya BELITOVA (100 Bulgaria), Elias FADEL (48 Bahrain), Tarkan YETISYIGIT (48 Bahrain), Yasemin CAG (792 Turkey), Sevil ALKAN (792 Turkey), Bircan KAYAASLAN (792 Turkey), Serkan ONCU (792 Turkey), Mehmet OZDEMIR (792 Turkey), Mesut YILMAZ (792 Turkey), Arzu Cennet ISIK (792 Turkey), Dilsah BASKOL (792 Turkey), Gulden SINCAN (792 Turkey), Antonio CASCIO (380 Italy), Safak OZER-BALIN (792 Turkey), Nesibe KORKMAZ (792 Turkey), Rezaul Karim RIPON (50 Bangladesh), Salma ABBAS (586 Pakistan), Irina Magdalena DUMITRU (642 Romania), Gulden ESER-KARLIDAG (792 Turkey), Massimiliano LANZAFAME (380 Italy), Abdur RAFEY (586 Pakistan), Aun RAZA (586 Pakistan), Oguz Resat SIPAHI (792 Turkey), Ilad Alavi DARAZAM (364 Islamic Republic of Iran), Umran ELBAHR (48 Bahrain), Ilknur ERDEM (792 Turkey), Pinar ERGEN (792 Turkey), Cemil BILIR (792 Turkey), Hulya CASKURLU (792 Turkey), Aysegul ERDEM (792 Turkey), Mateja Jankovic MAKEK (191 Croatia), Mustafa ALTINDIS (792 Turkey), Botond LAKATOS (348 Hungary), Catalina Mihaela LUCA (642 Romania), Esmeray Mutlu YILMAZ (792 Turkey), Emmanuel NSUTEBU (784 United Arab Emirates), Rumeysa CAKMAK (792 Turkey) and Fatma SIRMATEL (792 Turkey)

Edition

International Journal of Antimicrobial Agents, Amsterdam, Netherlands, Elsevier Ltd, 2023, 0924-8579

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.800 in 2022

RIV identification code

RIV/00216224:14110/23:00131722

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ijantimicag.2023.106919

UT WoS

001063127400001

Keywords in English

Febrile neutropenia; Bacteraemia; Antimicrobial; Resistance; Antibiotic stewardship

Abstract

V originále

Objectives: Bacteraemia during the course of neutropenia is often fatal. We aimed to identify factors predicting mortality to have an insight into better clinical management.Methods: The study has a prospective, observational design using pooled data from febrile neutropenia patients with bacteraemia in 41 centres in 16 countries. Polymicrobial bacteraemias were excluded. It was performed through the Infectious Diseases-International Research Initiative platform between 17 March 2021 and June 2021. Univariate analysis followed by a multivariate binary logistic regression model was used to determine independent predictors of 30-d in-hospital mortality (sensitivity, 81.2%; specificity, 65%). Results: A total of 431 patients were enrolled, and 85 (19.7%) died. Haematological malignancies were detected in 361 (83.7%) patients. Escherichia coli (n = 117, 27.1%), Klebsiellae (n = 95, 22% %), Pseudomonadaceae (n = 63, 14.6%), Coagulase-negative Staphylococci (n = 57, 13.2%), Staphylococcus aureus (n = 30, 7%), and Enterococci (n = 21, 4.9%) were the common pathogens. Meropenem and piperacillin-tazobactam susceptibility, among the isolated pathogens, were only 66.1% and 53.6%, respectively. Pulse rate (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002-1.034), quick SOFA score (OR, 2.857; 95% CI, 2.120- 3.851), inappropriate antimicrobial treatment (OR, 1.774; 95% CI, 1.011-3.851), Gram-negative bacteraemia (OR, 2.894; 95% CI, 1.437-5.825), bacteraemia of non-urinary origin (OR, 11.262; 95% CI, 1.368-92.720), and advancing age (OR, 1.017; 95% CI, 1.001-1.034) were independent predictors of mortality. Bacteraemia in our neutropenic patient population had distinctive characteristics. The severity of infection and the way to control it with appropriate antimicrobials, and local epidemiological data, came forward. Conclusions: Local antibiotic susceptibility profiles should be integrated into therapeutic recommendations, and infection control and prevention measures should be prioritised in this era of rapidly increasing antibiotic resistance.

Citovat

ERDEM, Hakan, Esra KOCOGLU, Handan ANKARALI, Rehab EL-SOKKARY, Atousa HAKAMIFARD, Ridvan KARAALI, Sholpan KULZHANOVA, Amani EL-KHOLY, Hamed Azhdari TEHRANI, Reham KHEDR, Ayse KAYA-KALEM, Nenad PANDAK, Meliha CAGLA-SONMEZER, Summiya NIZAMUDDIN, Hande BERK-CAM, Rahmet GUNER, Jehan Ali ELKHOLY, Ferran LLOPIS, Andrea MARINO, Roman STEBEL, Balint Gergely SZABO, Maya BELITOVA, Elias FADEL, Tarkan YETISYIGIT, Yasemin CAG, Sevil ALKAN, Bircan KAYAASLAN, Serkan ONCU, Mehmet OZDEMIR, Mesut YILMAZ, Arzu Cennet ISIK, Dilsah BASKOL, Gulden SINCAN, Antonio CASCIO, Safak OZER-BALIN, Nesibe KORKMAZ, Rezaul Karim RIPON, Salma ABBAS, Irina Magdalena DUMITRU, Gulden ESER-KARLIDAG, Massimiliano LANZAFAME, Abdur RAFEY, Aun RAZA, Oguz Resat SIPAHI, Ilad Alavi DARAZAM, Umran ELBAHR, Ilknur ERDEM, Pinar ERGEN, Cemil BILIR, Hulya CASKURLU, Aysegul ERDEM, Mateja Jankovic MAKEK, Mustafa ALTINDIS, Botond LAKATOS, Catalina Mihaela LUCA, Esmeray Mutlu YILMAZ, Emmanuel NSUTEBU, Rumeysa CAKMAK and Fatma SIRMATEL. Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study. International Journal of Antimicrobial Agents. Amsterdam, Netherlands: Elsevier Ltd, 2023, vol. 62, No 3, p. 1-10. ISSN 0924-8579. Available from: https://dx.doi.org/10.1016/j.ijantimicag.2023.106919.

@article{2313317,
   author = {Erdem, Hakan and Kocoglu, Esra and Ankarali, Handan and ElandSokkary, Rehab and Hakamifard, Atousa and Karaali, Ridvan and Kulzhanova, Sholpan and ElandKholy, Amani and Tehrani, Hamed Azhdari and Khedr, Reham and KayaandKalem, Ayse and Pandak, Nenad and CaglaandSonmezer, Meliha and Nizamuddin, Summiya and BerkandCam, Hande and Guner, Rahmet and Elkholy, Jehan Ali and Llopis, Ferran and Marino, Andrea and Stebel, Roman and Szabo, Balint Gergely and Belitova, Maya and Fadel, Elias and Yetisyigit, Tarkan and Cag, Yasemin and Alkan, Sevil and Kayaaslan, Bircan and Oncu, Serkan and Ozdemir, Mehmet and Yilmaz, Mesut and Isik, Arzu Cennet and Baskol, Dilsah and Sincan, Gulden and Cascio, Antonio and OzerandBalin, Safak and Korkmaz, Nesibe and Ripon, Rezaul Karim and Abbas, Salma and Dumitru, Irina Magdalena and EserandKarlidag, Gulden and Lanzafame, Massimiliano and Rafey, Abdur and Raza, Aun and Sipahi, Oguz Resat and Darazam, Ilad Alavi and Elbahr, Umran and Erdem, Ilknur and Ergen, Pinar and Bilir, Cemil and Caskurlu, Hulya and Erdem, Aysegul and Makek, Mateja Jankovic and Altindis, Mustafa and Lakatos, Botond and Luca, Catalina Mihaela and Yilmaz, Esmeray Mutlu and Nsutebu, Emmanuel and Cakmak, Rumeysa and Sirmatel, Fatma},
   article_location = {Amsterdam, Netherlands},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.ijantimicag.2023.106919},
   keywords = {Febrile neutropenia; Bacteraemia; Antimicrobial; Resistance; Antibiotic stewardship},
   language = {eng},
   issn = {0924-8579},
   journal = {International Journal of Antimicrobial Agents},
   title = {Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study},
   url = {https://www.sciencedirect.com/science/article/pii/S092485792300198X},
   volume = {62},
   year = {2023}
}

TY  - JOUR
ID  - 2313317
AU  - Erdem, Hakan - Kocoglu, Esra - Ankarali, Handan - El-Sokkary, Rehab - Hakamifard, Atousa - Karaali, Ridvan - Kulzhanova, Sholpan - El-Kholy, Amani - Tehrani, Hamed Azhdari - Khedr, Reham - Kaya-Kalem, Ayse - Pandak, Nenad - Cagla-Sonmezer, Meliha - Nizamuddin, Summiya - Berk-Cam, Hande - Guner, Rahmet - Elkholy, Jehan Ali - Llopis, Ferran - Marino, Andrea - Stebel, Roman - Szabo, Balint Gergely - Belitova, Maya - Fadel, Elias - Yetisyigit, Tarkan - Cag, Yasemin - Alkan, Sevil - Kayaaslan, Bircan - Oncu, Serkan - Ozdemir, Mehmet - Yilmaz, Mesut - Isik, Arzu Cennet - Baskol, Dilsah - Sincan, Gulden - Cascio, Antonio - Ozer-Balin, Safak - Korkmaz, Nesibe - Ripon, Rezaul Karim - Abbas, Salma - Dumitru, Irina Magdalena - Eser-Karlidag, Gulden - Lanzafame, Massimiliano - Rafey, Abdur - Raza, Aun - Sipahi, Oguz Resat - Darazam, Ilad Alavi - Elbahr, Umran - Erdem, Ilknur - Ergen, Pinar - Bilir, Cemil - Caskurlu, Hulya - Erdem, Aysegul - Makek, Mateja Jankovic - Altindis, Mustafa - Lakatos, Botond - Luca, Catalina Mihaela - Yilmaz, Esmeray Mutlu - Nsutebu, Emmanuel - Cakmak, Rumeysa - Sirmatel, Fatma
PY  - 2023
TI  - Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study
JF  - International Journal of Antimicrobial Agents
VL  - 62
IS  - 3
SP  - 1-10
EP  - 1-10
PB  - Elsevier Ltd
SN  - 09248579
KW  - Febrile neutropenia
KW  - Bacteraemia
KW  - Antimicrobial
KW  - Resistance
KW  - Antibiotic stewardship
UR  - https://www.sciencedirect.com/science/article/pii/S092485792300198X
N2  - Objectives: Bacteraemia during the course of neutropenia is often fatal. We aimed to identify factors predicting mortality to have an insight into better clinical management.Methods: The study has a prospective, observational design using pooled data from febrile neutropenia patients with bacteraemia in 41 centres in 16 countries. Polymicrobial bacteraemias were excluded. It was performed through the Infectious Diseases-International Research Initiative platform between 17 March 2021 and June 2021. Univariate analysis followed by a multivariate binary logistic regression model was used to determine independent predictors of 30-d in-hospital mortality (sensitivity, 81.2%; specificity, 65%). Results: A total of 431 patients were enrolled, and 85 (19.7%) died. Haematological malignancies were detected in 361 (83.7%) patients. Escherichia coli (n = 117, 27.1%), Klebsiellae (n = 95, 22% %), Pseudomonadaceae (n = 63, 14.6%), Coagulase-negative Staphylococci (n = 57, 13.2%), Staphylococcus aureus (n = 30, 7%), and Enterococci (n = 21, 4.9%) were the common pathogens. Meropenem and piperacillin-tazobactam susceptibility, among the isolated pathogens, were only 66.1% and 53.6%, respectively. Pulse rate (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002-1.034), quick SOFA score (OR, 2.857; 95% CI, 2.120- 3.851), inappropriate antimicrobial treatment (OR, 1.774; 95% CI, 1.011-3.851), Gram-negative bacteraemia (OR, 2.894; 95% CI, 1.437-5.825), bacteraemia of non-urinary origin (OR, 11.262; 95% CI, 1.368-92.720), and advancing age (OR, 1.017; 95% CI, 1.001-1.034) were independent predictors of mortality. Bacteraemia in our neutropenic patient population had distinctive characteristics. The severity of infection and the way to control it with appropriate antimicrobials, and local epidemiological data, came forward. Conclusions: Local antibiotic susceptibility profiles should be integrated into therapeutic recommendations, and infection control and prevention measures should be prioritised in this era of rapidly increasing antibiotic resistance.
ER  -

ERDEM, Hakan, Esra KOCOGLU, Handan ANKARALI, Rehab EL-SOKKARY, Atousa HAKAMIFARD, Ridvan KARAALI, Sholpan KULZHANOVA, Amani EL-KHOLY, Hamed Azhdari TEHRANI, Reham KHEDR, Ayse KAYA-KALEM, Nenad PANDAK, Meliha CAGLA-SONMEZER, Summiya NIZAMUDDIN, Hande BERK-CAM, Rahmet GUNER, Jehan Ali ELKHOLY, Ferran LLOPIS, Andrea MARINO, Roman STEBEL, Balint Gergely SZABO, Maya BELITOVA, Elias FADEL, Tarkan YETISYIGIT, Yasemin CAG, Sevil ALKAN, Bircan KAYAASLAN, Serkan ONCU, Mehmet OZDEMIR, Mesut YILMAZ, Arzu Cennet ISIK, Dilsah BASKOL, Gulden SINCAN, Antonio CASCIO, Safak OZER-BALIN, Nesibe KORKMAZ, Rezaul Karim RIPON, Salma ABBAS, Irina Magdalena DUMITRU, Gulden ESER-KARLIDAG, Massimiliano LANZAFAME, Abdur RAFEY, Aun RAZA, Oguz Resat SIPAHI, Ilad Alavi DARAZAM, Umran ELBAHR, Ilknur ERDEM, Pinar ERGEN, Cemil BILIR, Hulya CASKURLU, Aysegul ERDEM, Mateja Jankovic MAKEK, Mustafa ALTINDIS, Botond LAKATOS, Catalina Mihaela LUCA, Esmeray Mutlu YILMAZ, Emmanuel NSUTEBU, Rumeysa CAKMAK and Fatma SIRMATEL. Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study. \textit{International Journal of Antimicrobial Agents}. Amsterdam, Netherlands: Elsevier Ltd, 2023, vol.~62, No~3, p.~1-10. ISSN~0924-8579. Available from: https://dx.doi.org/10.1016/j.ijantimicag.2023.106919.

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