Other formats:
BibTeX
LaTeX
RIS
@article{2314698, author = {Qiu, Tengyang and Hutečková, Barbora and Seppala, Maisa and Cobourne, Martyn T and Chen, Zhi and Hovořáková, Mária and Buchtová, Marcela and Tucker, Abigail S}, article_number = {7}, doi = {http://dx.doi.org/10.1242/dev.201464}, keywords = {Vestibular lamina; Oral cavity; Sonic hedgehog; Gas1; Dental lamina; Ciliopathies; Mouse}, language = {eng}, issn = {0950-1991}, journal = {Development}, title = {Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling}, url = {https://doi.org/10.1242/dev.201464}, volume = {150}, year = {2023} }
TY - JOUR ID - 2314698 AU - Qiu, Tengyang - Hutečková, Barbora - Seppala, Maisa - Cobourne, Martyn T - Chen, Zhi - Hovořáková, Mária - Buchtová, Marcela - Tucker, Abigail S PY - 2023 TI - Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling JF - Development VL - 150 IS - 7 SP - 1-13 EP - 1-13 PB - Company of Biologists Ltd SN - 09501991 KW - Vestibular lamina KW - Oral cavity KW - Sonic hedgehog KW - Gas1 KW - Dental lamina KW - Ciliopathies KW - Mouse UR - https://doi.org/10.1242/dev.201464 N2 - The vestibular lamina (VL) forms the oral vestibule, creating a gap between the teeth, lips and cheeks. In a number of ciliopathies, formation of the vestibule is defective, leading to the creation of multiple frenula. In contrast to the neighbouring dental lamina, which forms the teeth, little is known about the genes that pattern the VL. Here, we establish a molecular signature for the usually non-odontogenic VL in mice and highlight several genes and signalling pathways that may play a role in its development. For one of these, the Sonic hedgehog (Shh) pathway, we show that co-receptors Gas1, Cdon and Boc are highly expressed in the VL and act to enhance the Shh signal from the forming incisor region. In Gas1 mutant mice, expression of Gli1 was disrupted and the VL epithelium failed to extend due to a loss of proliferation. This defect was exacerbated in Boc/Gas1 double mutants and could be phenocopied using cyclopamine in culture. Signals from the forming teeth, therefore, control development of the VL, coordinating the development of the dentition and the oral cavity. ER -
QIU, Tengyang, Barbora HUTEČKOVÁ, Maisa SEPPALA, Martyn T COBOURNE, Zhi CHEN, Mária HOVOŘÁKOVÁ, Marcela BUCHTOVÁ and Abigail S TUCKER. Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling. \textit{Development}. Company of Biologists Ltd, 2023, vol.~150, No~7, p.~1-13. ISSN~0950-1991. Available from: https://dx.doi.org/10.1242/dev.201464.
|