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@article{2322597,
author = {Baishya, Kaushik and Vrchovecká, Kateřina and Alijani, Mahnaz and RodriguezandPereira, Jhonatan and Thalluri, Sitaramanjaneya Mouli and Pávková Goldbergová, Monika and Přibyl, Jan and Macak, Jan M.},
article_location = {AMSTERDAM},
article_number = {December 2023},
doi = {http://dx.doi.org/10.1016/j.apsadv.2023.100459},
keywords = {TiO2; Nanotubeh; GFs; Ti foils; Atomic layer deposition; Bio-AFM},
language = {eng},
issn = {2666-5239},
journal = {Applied Surface Science Advances},
title = {Bio-AFM exploits enhanced response of human gingival fibroblasts on TiO2 nanotubular substrates with thin TiO2 coatings},
url = {https://www.sciencedirect.com/science/article/pii/S2666523923000934},
volume = {18},
year = {2023}
}
TY - JOUR
ID - 2322597
AU - Baishya, Kaushik - Vrchovecká, Kateřina - Alijani, Mahnaz - Rodriguez-Pereira, Jhonatan - Thalluri, Sitaramanjaneya Mouli - Pávková Goldbergová, Monika - Přibyl, Jan - Macak, Jan M.
PY - 2023
TI - Bio-AFM exploits enhanced response of human gingival fibroblasts on TiO2 nanotubular substrates with thin TiO2 coatings
JF - Applied Surface Science Advances
VL - 18
IS - December 2023
SP - 1-12
EP - 1-12
PB - ELSEVIER
SN - 26665239
KW - TiO2
KW - Nanotubeh
KW - GFs
KW - Ti foils
KW - Atomic layer deposition
KW - Bio-AFM
UR - https://www.sciencedirect.com/science/article/pii/S2666523923000934
N2 - The present work studies anodic TiO2 nanotube (TNT) layers and their surface modifications for enhancing the cell behavior of human gingival fibroblast cells (hGFs) with the contribution of bio-AFM (Atomic Force Microscopy) method. TNT layers, prepared via electrochemical anodization of Ti, with an average tube diameter of 15, 30, and 100 nm, were used as primary substrates for the study. Flat Ti foils were used as reference substrates. Part of the substrates was coated by ultrathin TiO2 coatings (≈ 0.3 nm thin) using Atomic Layer Deposition (ALD). The cell growth and adhesion of hGFs on the TNT layers and Ti foils were compared between ALD coated and uncoated ones. The supplemental coatings altered the surface chemistry of the TNT layers, particularly shading the fluorine and carbon impurities within anodic TiO2, while preserving the original structure and morphology. The presented approach of very mild surface modification remarkably effects the material's biocompatibility and possess great prospect as implant materials. For the first time, the TNT/cell interface was investigated using bio-AFM in terms of Young's modulus, stiffness, cell adhesive force and roughness. Improved biocompatibility was studied in terms of increased cell viability, density, cell cytoskeleton orientation and overall stiffness of the hGFs.
ER -
BAISHYA, Kaushik, Kateřina VRCHOVECKÁ, Mahnaz ALIJANI, Jhonatan RODRIGUEZ-PEREIRA, Sitaramanjaneya Mouli THALLURI, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan PŘIBYL and Jan M. MACAK. Bio-AFM exploits enhanced response of human gingival fibroblasts on TiO2 nanotubular substrates with thin TiO2 coatings. \textit{Applied Surface Science Advances}. AMSTERDAM: ELSEVIER, 2023, vol.~18, December 2023, p.~1-12. ISSN~2666-5239. Available from: https://dx.doi.org/10.1016/j.apsadv.2023.100459.
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