| SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK, Jitka STYBLOVA, Vladimír MIXA and Barbora NEDOMOVA. Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours. Bratislava Medical Journal - Bratislavské lekárske listy. BRATISLAVA: Univerzita Komenského, 2023, vol. 124, No 2, p. 116-120. ISSN 0006-9248. Available from: https://dx.doi.org/10.4149/BLL_2023_018. |
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@article{2327140,
author = {Sipek, Jan and Pokorna, Pavla and Sima, Martin and Berka, Ivan and Hlozek, Tomas and Styblova, Jitka and Mixa, Vladimír and Nedomova, Barbora},
article_location = {BRATISLAVA},
article_number = {2},
doi = {http://dx.doi.org/10.4149/BLL_2023_018},
keywords = {free levobupivacaine; total levobupivacaine; neonate; caudal continuous epidural analgesia; postoperative pain},
language = {eng},
issn = {0006-9248},
journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
title = {Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours},
url = {http://www.elis.sk/download_file.php?product_id=7918&session_id=cd662gp9iqhqdidiu9pr02vda0},
volume = {124},
year = {2023}
}
TY - JOUR
ID - 2327140
AU - Sipek, Jan - Pokorna, Pavla - Sima, Martin - Berka, Ivan - Hlozek, Tomas - Styblova, Jitka - Mixa, Vladimír - Nedomova, Barbora
PY - 2023
TI - Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours
JF - Bratislava Medical Journal - Bratislavské lekárske listy
VL - 124
IS - 2
SP - 116-120
EP - 116-120
PB - Univerzita Komenského
SN - 00069248
KW - free levobupivacaine
KW - total levobupivacaine
KW - neonate
KW - caudal continuous epidural analgesia
KW - postoperative pain
UR - http://www.elis.sk/download_file.php?product_id=7918&session_id=cd662gp9iqhqdidiu9pr02vda0
N2 - BACKGROUND: Differences in neonatal pharmacokinetics are known to cause systemic accumulation of levobupivacaine with adverse effects during epidural analgesia. Therefore, it is not recommended to surpass 48 hours of administration in neonates. Free and total levobupivacaine levels are considered as predictors of toxicity.
ER -
SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK, Jitka STYBLOVA, Vladimír MIXA and Barbora NEDOMOVA. Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2023, vol.~124, No~2, p.~116-120. ISSN~0006-9248. Available from: https://dx.doi.org/10.4149/BLL\_{}2023\_{}018.
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