Plasma concentrations of levobupivacaine in neonates during
caudal epidural analgesia maintained over 48 hours

J 2023

Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours

SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK et. al.

Basic information

Original name

Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours

Authors

SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK, Jitka STYBLOVA, Vladimír MIXA (203 Czech Republic, guarantor, belonging to the institution) and Barbora NEDOMOVA

Edition

Bratislava Medical Journal - Bratislavské lekárske listy, BRATISLAVA, Univerzita Komenského, 2023, 0006-9248

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30230 Other clinical medicine subjects

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.500 in 2022

RIV identification code

RIV/00216224:14110/23:00131955

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4149/BLL_2023_018

UT WoS

000916937100005

Keywords (in Czech)

free levobupivacaine; total levobupivacaine; neonate; caudal continuous epidural analgesia; postoperative pain

Keywords in English

free levobupivacaine; total levobupivacaine; neonate; caudal continuous epidural analgesia; postoperative pain

Abstract

V originále

BACKGROUND: Differences in neonatal pharmacokinetics are known to cause systemic accumulation of levobupivacaine with adverse effects during epidural analgesia. Therefore, it is not recommended to surpass 48 hours of administration in neonates. Free and total levobupivacaine levels are considered as predictors of toxicity.

Links

90249, large research infrastructures

Name: CZECRIN IV

Citovat

SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK, Jitka STYBLOVA, Vladimír MIXA and Barbora NEDOMOVA. Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours. Bratislava Medical Journal - Bratislavské lekárske listy. BRATISLAVA: Univerzita Komenského, 2023, vol. 124, No 2, p. 116-120. ISSN 0006-9248. Available from: https://dx.doi.org/10.4149/BLL_2023_018.

@article{2327140,
   author = {Sipek, Jan and Pokorna, Pavla and Sima, Martin and Berka, Ivan and Hlozek, Tomas and Styblova, Jitka and Mixa, Vladimír and Nedomova, Barbora},
   article_location = {BRATISLAVA},
   article_number = {2},
   doi = {http://dx.doi.org/10.4149/BLL_2023_018},
   keywords = {free levobupivacaine; total levobupivacaine; neonate; caudal continuous epidural analgesia; postoperative pain},
   language = {eng},
   issn = {0006-9248},
   journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
   title = {Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours},
   url = {http://www.elis.sk/download_file.php?product_id=7918&session_id=cd662gp9iqhqdidiu9pr02vda0},
   volume = {124},
   year = {2023}
}

TY  - JOUR
ID  - 2327140
AU  - Sipek, Jan - Pokorna, Pavla - Sima, Martin - Berka, Ivan - Hlozek, Tomas - Styblova, Jitka - Mixa, Vladimír - Nedomova, Barbora
PY  - 2023
TI  - Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours
JF  - Bratislava Medical Journal - Bratislavské lekárske listy
VL  - 124
IS  - 2
SP  - 116-120
EP  - 116-120
PB  - Univerzita Komenského
SN  - 00069248
KW  - free levobupivacaine
KW  - total levobupivacaine
KW  - neonate
KW  - caudal continuous epidural analgesia
KW  - postoperative pain
UR  - http://www.elis.sk/download_file.php?product_id=7918&session_id=cd662gp9iqhqdidiu9pr02vda0
N2  - BACKGROUND: Differences in neonatal pharmacokinetics are known to cause systemic accumulation of levobupivacaine with adverse effects during epidural analgesia. Therefore, it is not recommended to surpass 48 hours of administration in neonates. Free and total levobupivacaine levels are considered as predictors of toxicity.
ER  -

SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK, Jitka STYBLOVA, Vladimír MIXA and Barbora NEDOMOVA. Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2023, vol.~124, No~2, p.~116-120. ISSN~0006-9248. Available from: https://dx.doi.org/10.4149/BLL\_{}2023\_{}018.

Detailed Information on Publication Record