Effect of novel carboxymethyl cellulose-based dressings on
acute wound healing dynamics

J 2023

Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics

KRUŽICOVÁ, Alžběta, Marta CHALUPOVÁ, Gabriela KUZMÍNOVÁ, Tomáš PARÁK, Jarmila KLUSÁKOVÁ et. al.

Basic information

Original name

Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics

Name in Czech

Efekt nového krytí na bázi karboxymethycelulózy na dynamiku hojení akutní rány

Authors

KRUŽICOVÁ, Alžběta (203 Czech Republic, guarantor, belonging to the institution), Marta CHALUPOVÁ (203 Czech Republic, belonging to the institution), Gabriela KUZMÍNOVÁ (203 Czech Republic, belonging to the institution), Tomáš PARÁK (203 Czech Republic, belonging to the institution), Jarmila KLUSÁKOVÁ (203 Czech Republic), Tomas SOPUCH and Pavel SUCHÝ (203 Czech Republic, belonging to the institution)

Edition

Veterinarni Medicina, Prague, CZECH ACAD AGRIC SCI, 2023, 0375-8427

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.700 in 2022

RIV identification code

RIV/00216224:14160/23:00134513

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.17221/89/2023-VETMED

UT WoS

001098482400003

Keywords in English

cytokines; growth factors; wound dressing; Wistar rat

Abstract

V originále

The clinical implications and efficacy of newly developed modified cellulose materials were evaluated in an acute wound animal model. In the current study, sixty male rats were divided into four groups. A full-thickness circular excision wound was created in the suprascapular area. Newly developed matrices (acidic partially carboxymethylated cellulose; acidic partially carboxymethylated cellulose impregnated with a povidone-io dine solution) were applied in two test groups, while fifteen animals were used as a control group without any primary dressing. Aquacel Ag, a clinically used dressing, was selected as the reference material. To compare the efficacy in vivo, the wound size and production of selected cytokines and growth factors (TNF-alpha, TGF-131, and VEGF), which play a key role in the healing process, were measured at two, seven, and fourteen days after surgery. The activity of matrix metalloproteinases 2 and 9, which actively participate in cell signalling and are essential for tissue remodelling, was determined in wound tissue by gelatin zymography. A positive effect of the newly developed dressing materials on the healing process, tissue granulation, and wound re-epithelialisation was demonstrated.

Links

TH04020540, research and development project

Name: Nová bioaktivní hemostatika a krytí ran na bázi kolagenu a celulózy

Investor: Technology Agency of the Czech Republic

Citovat

KRUŽICOVÁ, Alžběta, Marta CHALUPOVÁ, Gabriela KUZMÍNOVÁ, Tomáš PARÁK, Jarmila KLUSÁKOVÁ, Tomas SOPUCH and Pavel SUCHÝ. Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics. Veterinarni Medicina. Prague: CZECH ACAD AGRIC SCI, 2023, vol. 68, No 10, p. 403-411. ISSN 0375-8427. Available from: https://dx.doi.org/10.17221/89/2023-VETMED.

@article{2327377,
   author = {Kružicová, Alžběta and Chalupová, Marta and Kuzmínová, Gabriela and Parák, Tomáš and Klusáková, Jarmila and Sopuch, Tomas and Suchý, Pavel},
   article_location = {Prague},
   article_number = {10},
   doi = {http://dx.doi.org/10.17221/89/2023-VETMED},
   keywords = {cytokines; growth factors; wound dressing; Wistar rat},
   language = {eng},
   issn = {0375-8427},
   journal = {Veterinarni Medicina},
   title = {Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics},
   url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666658/pdf/VETMED-68-10-123089.pdf},
   volume = {68},
   year = {2023}
}

TY  - JOUR
ID  - 2327377
AU  - Kružicová, Alžběta - Chalupová, Marta - Kuzmínová, Gabriela - Parák, Tomáš - Klusáková, Jarmila - Sopuch, Tomas - Suchý, Pavel
PY  - 2023
TI  - Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics
JF  - Veterinarni Medicina
VL  - 68
IS  - 10
SP  - 403-411
EP  - 403-411
PB  - CZECH ACAD AGRIC SCI
SN  - 03758427
KW  - cytokines
KW  - growth factors
KW  - wound dressing
KW  - Wistar rat
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666658/pdf/VETMED-68-10-123089.pdf
N2  - The clinical implications and efficacy of newly developed modified cellulose materials were evaluated in an acute wound animal model. In the current study, sixty male rats were divided into four groups. A full-thickness circular excision wound was created in the suprascapular area. Newly developed matrices (acidic partially carboxymethylated cellulose; acidic partially carboxymethylated cellulose impregnated with a povidone-io dine solution) were applied in two test groups, while fifteen animals were used as a control group without any primary dressing. Aquacel Ag, a clinically used dressing, was selected as the reference material. To compare the efficacy in vivo, the wound size and production of selected cytokines and growth factors (TNF-alpha, TGF-131, and VEGF), which play a key role in the healing process, were measured at two, seven, and fourteen days after surgery. The activity of matrix metalloproteinases 2 and 9, which actively participate in cell signalling and are essential for tissue remodelling, was determined in wound tissue by gelatin zymography. A positive effect of the newly developed dressing materials on the healing process, tissue granulation, and wound re-epithelialisation was demonstrated.
ER  -

KRUŽICOVÁ, Alžběta, Marta CHALUPOVÁ, Gabriela KUZMÍNOVÁ, Tomáš PARÁK, Jarmila KLUSÁKOVÁ, Tomas SOPUCH and Pavel SUCHÝ. Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics. \textit{Veterinarni Medicina}. Prague: CZECH ACAD AGRIC SCI, 2023, vol.~68, No~10, p.~403-411. ISSN~0375-8427. Available from: https://dx.doi.org/10.17221/89/2023-VETMED.

Detailed Information on Publication Record