Další formáty:
BibTeX
LaTeX
RIS
@article{2328278,
author = {Kubíčková, Vendula and Soukop, Jan and Rychlíčková, Jitka},
article_location = {Olomouc},
article_number = {3},
doi = {http://dx.doi.org/10.36290/far.2023.016},
keywords = {colistin; CMS; quantification methods; clinical samples; critically ill},
language = {eng},
issn = {1212-7973},
journal = {Klinicka Farmakologie a Farmacie},
title = {Assay of colistin A, B and colistin methanesulfonate in human plasma by LC-MS/MS and short-term plasma stability},
url = {https://www.klinickafarmakologie.cz/pdfs/far/2023/03/02.pdf},
volume = {37},
year = {2023}
}
TY - JOUR
ID - 2328278
AU - Kubíčková, Vendula - Soukop, Jan - Rychlíčková, Jitka
PY - 2023
TI - Assay of colistin A, B and colistin methanesulfonate in human plasma by LC-MS/MS and short-term plasma stability
JF - Klinicka Farmakologie a Farmacie
VL - 37
IS - 3
SP - 89-92
EP - 89-92
PB - SOLEN s.r.o.
SN - 12127973
KW - colistin
KW - CMS
KW - quantification methods
KW - clinical samples
KW - critically ill
UR - https://www.klinickafarmakologie.cz/pdfs/far/2023/03/02.pdf
N2 - A simple liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for the determination of colistin A and colistin B in human plasma was developed and validated. Plasma extraction was performed using Oasis HLB 1 ml cartridges, analysis was performed using Arion® Polar C18 (250×4,6mm; 5mm) column at 35°C. Mobile phases consisted of water containing 0,1% formic acid and methanol containing 0,1% formic acid (40:60, v/v) delivered at a flow rate of 0,8 ml/minute. Eluent was detected in the positive ion mode using electrospray ionization at the following transitions of mass to charge (m/z): colistin A 585,55 → 101,05; colistin B 578,5 → 101,15; and IS 602,4 → 101,1; 120,15; 86,15. Short-term stability tests of colistin and CMS were performed, at room temperature and 37°C, where the stability of both components decreases with increasing temperature. The presented paper is part of the Pharmacokinetics of Colistin in Critically Ill Patients With Extracorporeal Membrane Oxygenation (COL-ECMO2022) study in which further results will be presented.
ER -
KUBÍČKOVÁ, Vendula, Jan SOUKOP a Jitka RYCHLÍČKOVÁ. Assay of colistin A, B and colistin methanesulfonate in human plasma by LC-MS/MS and short-term plasma stability. \textit{Klinicka Farmakologie a Farmacie}. Olomouc: SOLEN s.r.o., 2023, roč.~37, č.~3, s.~89-92. ISSN~1212-7973. Dostupné z: https://dx.doi.org/10.36290/far.2023.016.
|
