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@article{2328278, author = {Kubíčková, Vendula and Soukop, Jan and Rychlíčková, Jitka}, article_location = {Olomouc}, article_number = {3}, doi = {http://dx.doi.org/10.36290/far.2023.016}, keywords = {colistin; CMS; quantification methods; clinical samples; critically ill}, language = {eng}, issn = {1212-7973}, journal = {Klinicka Farmakologie a Farmacie}, title = {Assay of colistin A, B and colistin methanesulfonate in human plasma by LC-MS/MS and short-term plasma stability}, url = {https://www.klinickafarmakologie.cz/pdfs/far/2023/03/02.pdf}, volume = {37}, year = {2023} }
TY - JOUR ID - 2328278 AU - Kubíčková, Vendula - Soukop, Jan - Rychlíčková, Jitka PY - 2023 TI - Assay of colistin A, B and colistin methanesulfonate in human plasma by LC-MS/MS and short-term plasma stability JF - Klinicka Farmakologie a Farmacie VL - 37 IS - 3 SP - 89-92 EP - 89-92 PB - SOLEN s.r.o. SN - 12127973 KW - colistin KW - CMS KW - quantification methods KW - clinical samples KW - critically ill UR - https://www.klinickafarmakologie.cz/pdfs/far/2023/03/02.pdf N2 - A simple liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for the determination of colistin A and colistin B in human plasma was developed and validated. Plasma extraction was performed using Oasis HLB 1 ml cartridges, analysis was performed using Arion® Polar C18 (250×4,6mm; 5mm) column at 35°C. Mobile phases consisted of water containing 0,1% formic acid and methanol containing 0,1% formic acid (40:60, v/v) delivered at a flow rate of 0,8 ml/minute. Eluent was detected in the positive ion mode using electrospray ionization at the following transitions of mass to charge (m/z): colistin A 585,55 → 101,05; colistin B 578,5 → 101,15; and IS 602,4 → 101,1; 120,15; 86,15. Short-term stability tests of colistin and CMS were performed, at room temperature and 37°C, where the stability of both components decreases with increasing temperature. The presented paper is part of the Pharmacokinetics of Colistin in Critically Ill Patients With Extracorporeal Membrane Oxygenation (COL-ECMO2022) study in which further results will be presented. ER -
KUBÍČKOVÁ, Vendula, Jan SOUKOP a Jitka RYCHLÍČKOVÁ. Assay of colistin A, B and colistin methanesulfonate in human plasma by LC-MS/MS and short-term plasma stability. \textit{Klinicka Farmakologie a Farmacie}. Olomouc: SOLEN s.r.o., 2023, roč.~37, č.~3, s.~89-92. ISSN~1212-7973. Dostupné z: https://dx.doi.org/10.36290/far.2023.016.
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