J 2023

A Pilot Study on the Functional Stability of Phonation in EEG Bands After Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease

GOMEZ-RODELLAR, Andres, Jiri MEKYSKA, Pedro GOMEZ-VILDA, Luboš BRABENEC, Patrik ŠIMKO et. al.

Basic information

Original name

A Pilot Study on the Functional Stability of Phonation in EEG Bands After Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease

Authors

GOMEZ-RODELLAR, Andres, Jiri MEKYSKA (203 Czech Republic), Pedro GOMEZ-VILDA, Luboš BRABENEC (203 Czech Republic, belonging to the institution), Patrik ŠIMKO (703 Slovakia, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, SINGAPORE, WORLD SCIENTIFIC PUBL CO PTE LTD, 2023, 0129-0657

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Singapore

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 8.000 in 2022

RIV identification code

RIV/00216224:14740/23:00132026

Organization unit

Central European Institute of Technology

DOI

UT WoS

000980189400001

Keywords in English

Parkinson's disease; functional quality assessment of phonation; acoustical EEG activity monitoring; repetitive transcranial magnetic stimulation

Tags

Tags

International impact, Reviewed
Změněno: 10/10/2024 13:22, Ing. Jana Kuchtová

Abstract

V originále

Parkinson's disease (PD) is a neurodegenerative condition with constantly increasing prevalence rates, affecting strongly life quality in terms of neuromotor and cognitive performance. PD symptoms include voice and speech alterations, known as hypokinetic dysarthria (HD). Unstable phonation is one of the manifestations of HD. Repetitive transcranial magnetic stimulation (rTMS) is a rehabilitative treatment thathas been shown to improve some motor and non-motor symptoms of persons with PD (PwP). This study analyzed the phonation functional behavior of 18 participants (13 males, 5 females) with PD diagnosis before (one pre-stimulus) and after (four post-stimulus) evaluation sessions of rTMS treatment, to assess the extent of changes in their phonation stability. Participants were randomized 1:1 to receive either rTMS or sham stimulation. Voice recordings of a sustained vowel [a:] taken immediately before and after the treatment, and at follow-up evaluation sessions (immediately after, at six, ten, and fourteen weeks after the baseline assessment) were processed by inverse filtering to estimate a biomechanical correlate of vocal fold tension. This estimate was further band-pass filtered into EEG-related frequency bands. Log-likelihood ratios (LLRs) between pre- and post-stimulus amplitude distributions of each frequency band showed significant differences in five cases actively stimulated. Seven cases submitted to the sham protocol did not show relevant improvements in phonation instability. Conversely, four active cases did not show phonation improvements, whereas two sham cases did. The study provides early preliminary insights into the capability of phonation quality assessment by monitoring neuromechanical activity from acoustic signals in frequency bands aligned with EEG ones.

Links

LX22NPO5107, research and development project
Name: Národní ústav pro neurologický výzkum
Investor: Ministry of Education, Youth and Sports of the CR, 5.1 EXCELES
NV16-30805A, research and development project
Name: Efekt neinvazivní stimulace mozku na hypokinetickou dysartrii, mikrografii a mozkovou plasticitu u pacientů s Parkinsonovou nemocí
734718, interní kód MU
Name: Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology (Acronym: CoBeN)
Investor: European Union, MSCA Marie Skłodowska-Curie Actions (Excellent Science)
90250, large research infrastructures
Name: Czech-BioImaging III