J 2024

Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight

KINCL, Vladimír, Roman PANOVSKÝ, Martina BOČKOVÁ, Ivan REKTOR, Mary Luz MOJICA-PISCIOTTI et. al.

Basic information

Original name

Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight

Authors

KINCL, Vladimír (203 Czech Republic, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, belonging to the institution), Martina BOČKOVÁ (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution), Mary Luz MOJICA-PISCIOTTI and Jan MÁCHAL (203 Czech Republic, belonging to the institution)

Edition

European Journal of Neurology, HOBOKEN, WILEY, 2024, 1351-5101

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 5.100 in 2022

Organization unit

Faculty of Medicine

DOI

UT WoS

001091935300001

Keywords in English

Parkinson´s disease; cardiovascular symptoms

Tags

Tags

International impact, Reviewed
Změněno: 2/4/2024 14:20, Mgr. Eva Dubská

Abstract

V originále

Background The known impairments of the cardiovascular system in Parkinson´s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research. Objectives To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients. Methods Thirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR). Results PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p < 0.01), peak SBP (155.8 vs. 170.8 mmHg, p < 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p < 0.01). PD patients had higher indexed left and right ventricular end-diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m2, respectively) and also indexed left and right ventricular end-systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m2, p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found. Conclusions This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.

Links

NU21-04-00445, research and development project
Name: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit (Acronym: DBScomorbidities)
Investor: Ministry of Health of the CR, STN-DBS outcomes in Parkinson´s disease: the influence of vascular, cardiovascular, metabolic, and inflammatory co-morbidities., Subprogram 1 - standard