| KELLER, Filip, Helena ANTONI, Petra MINARČÍKOVÁ, Ondřej HRDÝ and Roman GÁL. Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report. Antibiotics. BASEL: MDPI, 2023, vol. 12, No 10, p. 1-7. ISSN 2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12101489. |
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@article{2333257,
author = {Keller, Filip and Antoni, Helena and Minarčíková, Petra and Hrdý, Ondřej and Gál, Roman},
article_location = {BASEL},
article_number = {10},
doi = {http://dx.doi.org/10.3390/antibiotics12101489},
keywords = {mucormycosis; posaconazole; amphotericin B; severe trauma; case report},
language = {eng},
issn = {2079-6382},
journal = {Antibiotics},
title = {Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report},
url = {https://www.mdpi.com/2079-6382/12/10/1489},
volume = {12},
year = {2023}
}
TY - JOUR
ID - 2333257
AU - Keller, Filip - Antoni, Helena - Minarčíková, Petra - Hrdý, Ondřej - Gál, Roman
PY - 2023
TI - Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report
JF - Antibiotics
VL - 12
IS - 10
SP - 1-7
EP - 1-7
PB - MDPI
SN - 20796382
KW - mucormycosis
KW - posaconazole
KW - amphotericin B
KW - severe trauma
KW - case report
UR - https://www.mdpi.com/2079-6382/12/10/1489
N2 - Mucormycosis is an opportunistic infection affecting mainly immunocompromised hosts. Infection in immunocompetent patients is rare, but may occur typically in trauma or burn victims. We report on a previously healthy young man suffering devastating trauma from an agricultural accident with the subsequent development of a multifocal mucormycosis. Diagnosis was achieved by cultures obtained from non-healing wounds, some of them even covered by a macroscopic mold formation. Specific treatment was initiated soon after the preliminary results indicated mucormycosis. Aggressive surgical therapy, with concomitant use of systemic posaconazole and topical amphotericin B in a combination treatment, led to the elimination of the fungal infection. The remaining deep tissue defects were consequently reconstructed by a muscle flap and skin graft autotransplantation with a good overall outcome, which would not have been possible without the complete remission of mucormycosis. This case study presents the successful use of a combination treatment with systemic posaconazole and topical amphotericin B and underlines the importance of timely and aggressive surgical therapy.
ER -
KELLER, Filip, Helena ANTONI, Petra MINARČÍKOVÁ, Ondřej HRDÝ and Roman GÁL. Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report. \textit{Antibiotics}. BASEL: MDPI, 2023, vol.~12, No~10, p.~1-7. ISSN~2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12101489.
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