Mucormycosis in a Severe Trauma Patient Treated with a
Combination of Systemic Posaconazole and Topical Amphotericin
B—Case Report

J 2023

Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report

KELLER, Filip, Helena ANTONI, Petra MINARČÍKOVÁ, Ondřej HRDÝ, Roman GÁL et. al.

Basic information

Original name

Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report

Authors

KELLER, Filip (203 Czech Republic, belonging to the institution), Helena ANTONI (203 Czech Republic, belonging to the institution), Petra MINARČÍKOVÁ (203 Czech Republic, belonging to the institution), Ondřej HRDÝ (203 Czech Republic, belonging to the institution) and Roman GÁL (203 Czech Republic, belonging to the institution)

Edition

Antibiotics, BASEL, MDPI, 2023, 2079-6382

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30223 Anaesthesiology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.800 in 2022

RIV identification code

RIV/00216224:14110/23:00132096

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/antibiotics12101489

UT WoS

001090604100001

Keywords in English

mucormycosis; posaconazole; amphotericin B; severe trauma; case report

Abstract

V originále

Mucormycosis is an opportunistic infection affecting mainly immunocompromised hosts. Infection in immunocompetent patients is rare, but may occur typically in trauma or burn victims. We report on a previously healthy young man suffering devastating trauma from an agricultural accident with the subsequent development of a multifocal mucormycosis. Diagnosis was achieved by cultures obtained from non-healing wounds, some of them even covered by a macroscopic mold formation. Specific treatment was initiated soon after the preliminary results indicated mucormycosis. Aggressive surgical therapy, with concomitant use of systemic posaconazole and topical amphotericin B in a combination treatment, led to the elimination of the fungal infection. The remaining deep tissue defects were consequently reconstructed by a muscle flap and skin graft autotransplantation with a good overall outcome, which would not have been possible without the complete remission of mucormycosis. This case study presents the successful use of a combination treatment with systemic posaconazole and topical amphotericin B and underlines the importance of timely and aggressive surgical therapy.

Links

MUNI/A/1336/2022, interní kód MU

Name: Vliv profylaktického podání fibrinogenu na velikost krevní ztráty u operací skoliózy: Monocentrická randomizovaná pilotní studie

Investor: Masaryk University, Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery: A randomized pilot study

Citovat

KELLER, Filip, Helena ANTONI, Petra MINARČÍKOVÁ, Ondřej HRDÝ and Roman GÁL. Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report. Antibiotics. BASEL: MDPI, 2023, vol. 12, No 10, p. 1-7. ISSN 2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12101489.

@article{2333257,
   author = {Keller, Filip and Antoni, Helena and Minarčíková, Petra and Hrdý, Ondřej and Gál, Roman},
   article_location = {BASEL},
   article_number = {10},
   doi = {http://dx.doi.org/10.3390/antibiotics12101489},
   keywords = {mucormycosis; posaconazole; amphotericin B; severe trauma; case report},
   language = {eng},
   issn = {2079-6382},
   journal = {Antibiotics},
   title = {Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report},
   url = {https://www.mdpi.com/2079-6382/12/10/1489},
   volume = {12},
   year = {2023}
}

TY  - JOUR
ID  - 2333257
AU  - Keller, Filip - Antoni, Helena - Minarčíková, Petra - Hrdý, Ondřej - Gál, Roman
PY  - 2023
TI  - Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report
JF  - Antibiotics
VL  - 12
IS  - 10
SP  - 1-7
EP  - 1-7
PB  - MDPI
SN  - 20796382
KW  - mucormycosis
KW  - posaconazole
KW  - amphotericin B
KW  - severe trauma
KW  - case report
UR  - https://www.mdpi.com/2079-6382/12/10/1489
N2  - Mucormycosis is an opportunistic infection affecting mainly immunocompromised hosts. Infection in immunocompetent patients is rare, but may occur typically in trauma or burn victims. We report on a previously healthy young man suffering devastating trauma from an agricultural accident with the subsequent development of a multifocal mucormycosis. Diagnosis was achieved by cultures obtained from non-healing wounds, some of them even covered by a macroscopic mold formation. Specific treatment was initiated soon after the preliminary results indicated mucormycosis. Aggressive surgical therapy, with concomitant use of systemic posaconazole and topical amphotericin B in a combination treatment, led to the elimination of the fungal infection. The remaining deep tissue defects were consequently reconstructed by a muscle flap and skin graft autotransplantation with a good overall outcome, which would not have been possible without the complete remission of mucormycosis. This case study presents the successful use of a combination treatment with systemic posaconazole and topical amphotericin B and underlines the importance of timely and aggressive surgical therapy.
ER  -

KELLER, Filip, Helena ANTONI, Petra MINARČÍKOVÁ, Ondřej HRDÝ and Roman GÁL. Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report. \textit{Antibiotics}. BASEL: MDPI, 2023, vol.~12, No~10, p.~1-7. ISSN~2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12101489.

Detailed Information on Publication Record