A gene copy number arms race in action: X,Y-chromosome
transmission distortion across a species barrier

J 2023

A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier

BAIRD, Stuart J.E., Zuzana HIADLOVSKÁ, Kristina DANISZOVÁ, Jaroslav PIÁLEK, Miloš MACHOLÁN et. al.

Basic information

Original name

A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier

Authors

BAIRD, Stuart J.E. (guarantor), Zuzana HIADLOVSKÁ, Kristina DANISZOVÁ, Jaroslav PIÁLEK and Miloš MACHOLÁN (203 Czech Republic, belonging to the institution)

Edition

Evolution : international journal of organic evolution, Oxford University Press, 2023, 0014-3820

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10618 Ecology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL URL

Impact factor

Impact factor: 3.300 in 2022

RIV identification code

RIV/00216224:14310/23:00132105

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1093/evolut/qpad051

UT WoS

000963833400001

Keywords in English

hybridization; introgression; reproductive isolation; sex ratio; standing variation

Abstract

V originále

A remarkable gene copy number (CN) arms race system has recently been described in laboratory mice, where Slx;Slxl1 and Sly genes compete over transmission by altering the fertilization success of X and Y chromosome-bearing sperm, respectively. Here, we focus on this system in nature, where natural selection can counter CN/gene product escalation. Our model is house mouse subspecies hybridizing in Europe. In some regions, Y chromosomes of the Eastern subspecies have introgressed onto Western genomic backgrounds, accompanied by sex ratio distortion in favor of males, consistent with the inbred lines suggested mechanism: Overabundance of SLY protein expressed by invading Y chromosomes. We take Slx as representative of the X side of this arms race and measure Slx|Sly CN and expression across an "Invasion" transect where Ys introgress and a "Control" transect with negligible introgression. Since we found similar Slx|Sly ratios in both transects, SLY overabundance is unlikely to explain the introgression. However, Slx CN is relatively low in the introgression area, suggesting that Slx is less able to combat Sly effects here. Furthermore, deterministic changes in Slx;Sly expression proportions versus CN proportions suggest standing variation for trans regulation of Slx|Sly is being co-opted in nature where their arms race reduces population fitness.

Links

LM2010005, research and development project

Name: Velká infrastruktura CESNET (Acronym: VI CESNET)

Investor: Ministry of Education, Youth and Sports of the CR

LM2015091, research and development project

Name: Národní centrum lékařské genomiky (Acronym: NCLG)

Investor: Ministry of Education, Youth and Sports of the CR

90267, large research infrastructures

Name: NCMG III

Citovat

BAIRD, Stuart J.E., Zuzana HIADLOVSKÁ, Kristina DANISZOVÁ, Jaroslav PIÁLEK and Miloš MACHOLÁN. A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier. Evolution : international journal of organic evolution. Oxford University Press, 2023, vol. 77, No 6, p. 1330-1340. ISSN 0014-3820. Available from: https://dx.doi.org/10.1093/evolut/qpad051.

@article{2333538,
   author = {Baird, Stuart J.E. and Hiadlovská, Zuzana and Daniszová, Kristina and Piálek, Jaroslav and Macholán, Miloš},
   article_number = {6},
   doi = {http://dx.doi.org/10.1093/evolut/qpad051},
   keywords = {hybridization; introgression; reproductive isolation; sex ratio; standing variation},
   language = {eng},
   issn = {0014-3820},
   journal = {Evolution : international journal of organic evolution},
   title = {A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier},
   url = {https://doi.org/10.1093/evolut/qpad051},
   volume = {77},
   year = {2023}
}

TY  - JOUR
ID  - 2333538
AU  - Baird, Stuart J.E. - Hiadlovská, Zuzana - Daniszová, Kristina - Piálek, Jaroslav - Macholán, Miloš
PY  - 2023
TI  - A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier
JF  - Evolution : international journal of organic evolution
VL  - 77
IS  - 6
SP  - 1330-1340
EP  - 1330-1340
PB  - Oxford University Press
SN  - 00143820
KW  - hybridization
KW  - introgression
KW  - reproductive isolation
KW  - sex ratio
KW  - standing variation
UR  - https://doi.org/10.1093/evolut/qpad051
N2  - A remarkable gene copy number (CN) arms race system has recently been described in laboratory mice, where Slx;Slxl1 and Sly genes compete over transmission by altering the fertilization success of X and Y chromosome-bearing sperm, respectively. Here, we focus on this system in nature, where natural selection can counter CN/gene product escalation. Our model is house mouse subspecies hybridizing in Europe. In some regions, Y chromosomes of the Eastern subspecies have introgressed onto Western genomic backgrounds, accompanied by sex ratio distortion in favor of males, consistent with the inbred lines suggested mechanism: Overabundance of SLY protein expressed by invading Y chromosomes. We take Slx as representative of the X side of this arms race and measure Slx|Sly CN and expression across an "Invasion" transect where Ys introgress and a "Control" transect with negligible introgression. Since we found similar Slx|Sly ratios in both transects, SLY overabundance is unlikely to explain the introgression. However, Slx CN is relatively low in the introgression area, suggesting that Slx is less able to combat Sly effects here. Furthermore, deterministic changes in Slx;Sly expression proportions versus CN proportions suggest standing variation for trans regulation of Slx|Sly is being co-opted in nature where their arms race reduces population fitness.
ER  -

BAIRD, Stuart J.E., Zuzana HIADLOVSKÁ, Kristina DANISZOVÁ, Jaroslav PIÁLEK and Miloš MACHOLÁN. A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier. \textit{Evolution : international journal of organic evolution}. Oxford University Press, 2023, vol.~77, No~6, p.~1330-1340. ISSN~0014-3820. Available from: https://dx.doi.org/10.1093/evolut/qpad051.

Detailed Information on Publication Record