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@article{2335857,
author = {Mayerova, Lucie and Chaloupka, Anna and Wohlfahrt, Peter and Hubacek, Jaroslav Alois and Bedanova, Helena and Chen, Zhi and Kautzner, Josef and Melenovsky, Vojtech and Malek, Ivan and Tomasek, Ales and Ozábalová, Eva and Krejčí, Jan and Kovarnik, Tomas and Sonka, Milan and Pazdernik, Michal},
article_location = {BRATISLAVA},
article_number = {3},
doi = {http://dx.doi.org/10.4149/BLL_2023_031},
keywords = {cardiac allograft vasculopathy; optical coherence tomography; vascular endothelial growth factor A; intimal thickening; genetic polymorphism},
language = {eng},
issn = {0006-9248},
journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
title = {Role of genetics in the development of cardiac allograft vasculopathy},
url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7931&category_id=187&option=com_virtuemart&vmcchk=1&Itemid=1},
volume = {124},
year = {2023}
}
TY - JOUR
ID - 2335857
AU - Mayerova, Lucie - Chaloupka, Anna - Wohlfahrt, Peter - Hubacek, Jaroslav Alois - Bedanova, Helena - Chen, Zhi - Kautzner, Josef - Melenovsky, Vojtech - Malek, Ivan - Tomasek, Ales - Ozábalová, Eva - Krejčí, Jan - Kovarnik, Tomas - Sonka, Milan - Pazdernik, Michal
PY - 2023
TI - Role of genetics in the development of cardiac allograft vasculopathy
JF - Bratislava Medical Journal - Bratislavské lekárske listy
VL - 124
IS - 3
SP - 193-200
EP - 193-200
PB - Univerzita Komenského
SN - 00069248
KW - cardiac allograft vasculopathy
KW - optical coherence tomography
KW - vascular endothelial growth factor A
KW - intimal thickening
KW - genetic polymorphism
UR - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7931&category_id=187&option=com_virtuemart&vmcchk=1&Itemid=1
N2 - BACKGROUND: The association between genetic polymorphisms and early cardiac allograft vasculopathy (CAV) development is relatively unexplored. Identification of genes involved in the CAV process may offer new insights into pathophysiology and lead to a wider range of therapeutic options.METHODS: This prospective study of 109 patients investigated 44 single nucleotide polymorphisms (SNPs) within the susceptibility loci potentially related to coronary artery disease, carotid artery intima-media thickness (cIMT), and in nitric oxide synthase gene. Genotyping was done by the Fluidigm SNP Type assays and Fluidigm 48.48 Dynamic Array IFC. The intima thickness progression (IT) was evaluated by coronary optical coherence tomography (OCT) performed 1 month and 12 months after heart transplantation (HTx).RESULTS: During the first post-HTx year, the mean intima thickness (IT) increased by 24.0 +/- 34.2 mu m (p < 0.001) and lumen area decreased by -0.9 +/- 1.8 mm2 (p < 0.001). The rs1570360 (A/G) SNP of the vascular endothelial growth factor A (VEGFA) gene showed the strongest association with intima thickness progression, even in the presence of the traditional CAV risk factors. SNPs previously related to carotid artery intima-media thickness rs11785239 (PRAG1), rs6584389 (PAX2), rs13225723 (LINC02577) and rs17477177 (CCDC71L), were among the five most significantly associated with IT progression but lost their significance once traditional CAV risk factors had been added.CONCLUSION: Results of this study suggest that genetic variability may play an important role in CAV development. The vascular endothelial growth factor A gene SNP rs1570360 showed the strongest association with intima thickness (IT) progression measured by OCT, even in the presence of the traditional CAV risk factors (Tab. 3, Fig. 3, Ref. 36). Text in PDF www.elis.sk
ER -
MAYEROVA, Lucie, Anna CHALOUPKA, Peter WOHLFAHRT, Jaroslav Alois HUBACEK, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Ivan MALEK, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Tomas KOVARNIK, Milan SONKA and Michal PAZDERNIK. Role of genetics in the development of cardiac allograft vasculopathy. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2023, vol.~124, No~3, p.~193-200. ISSN~0006-9248. Available from: https://dx.doi.org/10.4149/BLL\_{}2023\_{}031.
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