Role of genetics in the development of cardiac allograft
vasculopathy

J 2023

Role of genetics in the development of cardiac allograft vasculopathy

MAYEROVA, Lucie, Anna CHALOUPKA, Peter WOHLFAHRT, Jaroslav Alois HUBACEK, Helena BEDANOVA et. al.

Basic information

Original name

Role of genetics in the development of cardiac allograft vasculopathy

Authors

MAYEROVA, Lucie (203 Czech Republic), Anna CHALOUPKA (203 Czech Republic, belonging to the institution), Peter WOHLFAHRT (203 Czech Republic), Jaroslav Alois HUBACEK (203 Czech Republic), Helena BEDANOVA (203 Czech Republic), Zhi CHEN, Josef KAUTZNER (203 Czech Republic), Vojtech MELENOVSKY (203 Czech Republic), Ivan MALEK (203 Czech Republic), Ales TOMASEK (203 Czech Republic), Eva OZÁBALOVÁ (203 Czech Republic, belonging to the institution), Jan KREJČÍ (203 Czech Republic, belonging to the institution), Tomas KOVARNIK (203 Czech Republic), Milan SONKA (203 Czech Republic) and Michal PAZDERNIK (203 Czech Republic, guarantor)

Edition

Bratislava Medical Journal - Bratislavské lekárske listy, BRATISLAVA, Univerzita Komenského, 2023, 0006-9248

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.500 in 2022

RIV identification code

RIV/00216224:14110/23:00132170

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4149/BLL_2023_031

UT WoS

000944162900006

Keywords in English

cardiac allograft vasculopathy; optical coherence tomography; vascular endothelial growth factor A; intimal thickening; genetic polymorphism

Abstract

V originále

BACKGROUND: The association between genetic polymorphisms and early cardiac allograft vasculopathy (CAV) development is relatively unexplored. Identification of genes involved in the CAV process may offer new insights into pathophysiology and lead to a wider range of therapeutic options.METHODS: This prospective study of 109 patients investigated 44 single nucleotide polymorphisms (SNPs) within the susceptibility loci potentially related to coronary artery disease, carotid artery intima-media thickness (cIMT), and in nitric oxide synthase gene. Genotyping was done by the Fluidigm SNP Type assays and Fluidigm 48.48 Dynamic Array IFC. The intima thickness progression (IT) was evaluated by coronary optical coherence tomography (OCT) performed 1 month and 12 months after heart transplantation (HTx).RESULTS: During the first post-HTx year, the mean intima thickness (IT) increased by 24.0 +/- 34.2 mu m (p < 0.001) and lumen area decreased by -0.9 +/- 1.8 mm2 (p < 0.001). The rs1570360 (A/G) SNP of the vascular endothelial growth factor A (VEGFA) gene showed the strongest association with intima thickness progression, even in the presence of the traditional CAV risk factors. SNPs previously related to carotid artery intima-media thickness rs11785239 (PRAG1), rs6584389 (PAX2), rs13225723 (LINC02577) and rs17477177 (CCDC71L), were among the five most significantly associated with IT progression but lost their significance once traditional CAV risk factors had been added.CONCLUSION: Results of this study suggest that genetic variability may play an important role in CAV development. The vascular endothelial growth factor A gene SNP rs1570360 showed the strongest association with intima thickness (IT) progression measured by OCT, even in the presence of the traditional CAV risk factors (Tab. 3, Fig. 3, Ref. 36). Text in PDF www.elis.sk

Links

MUNI/A/1410/2022, interní kód MU

Name: Nové trendy v diagnostice a managementu srdečních onemocnění

Investor: Masaryk University, New trends in diagnostics and management of cardiac diseases

Citovat

MAYEROVA, Lucie, Anna CHALOUPKA, Peter WOHLFAHRT, Jaroslav Alois HUBACEK, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Ivan MALEK, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Tomas KOVARNIK, Milan SONKA and Michal PAZDERNIK. Role of genetics in the development of cardiac allograft vasculopathy. Bratislava Medical Journal - Bratislavské lekárske listy. BRATISLAVA: Univerzita Komenského, 2023, vol. 124, No 3, p. 193-200. ISSN 0006-9248. Available from: https://dx.doi.org/10.4149/BLL_2023_031.

@article{2335857,
   author = {Mayerova, Lucie and Chaloupka, Anna and Wohlfahrt, Peter and Hubacek, Jaroslav Alois and Bedanova, Helena and Chen, Zhi and Kautzner, Josef and Melenovsky, Vojtech and Malek, Ivan and Tomasek, Ales and Ozábalová, Eva and Krejčí, Jan and Kovarnik, Tomas and Sonka, Milan and Pazdernik, Michal},
   article_location = {BRATISLAVA},
   article_number = {3},
   doi = {http://dx.doi.org/10.4149/BLL_2023_031},
   keywords = {cardiac allograft vasculopathy; optical coherence tomography; vascular endothelial growth factor A; intimal thickening; genetic polymorphism},
   language = {eng},
   issn = {0006-9248},
   journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
   title = {Role of genetics in the development of cardiac allograft vasculopathy},
   url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7931&category_id=187&option=com_virtuemart&vmcchk=1&Itemid=1},
   volume = {124},
   year = {2023}
}

TY  - JOUR
ID  - 2335857
AU  - Mayerova, Lucie - Chaloupka, Anna - Wohlfahrt, Peter - Hubacek, Jaroslav Alois - Bedanova, Helena - Chen, Zhi - Kautzner, Josef - Melenovsky, Vojtech - Malek, Ivan - Tomasek, Ales - Ozábalová, Eva - Krejčí, Jan - Kovarnik, Tomas - Sonka, Milan - Pazdernik, Michal
PY  - 2023
TI  - Role of genetics in the development of cardiac allograft vasculopathy
JF  - Bratislava Medical Journal - Bratislavské lekárske listy
VL  - 124
IS  - 3
SP  - 193-200
EP  - 193-200
PB  - Univerzita Komenského
SN  - 00069248
KW  - cardiac allograft vasculopathy
KW  - optical coherence tomography
KW  - vascular endothelial growth factor A
KW  - intimal thickening
KW  - genetic polymorphism
UR  - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7931&category_id=187&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - BACKGROUND: The association between genetic polymorphisms and early cardiac allograft vasculopathy (CAV) development is relatively unexplored. Identification of genes involved in the CAV process may offer new insights into pathophysiology and lead to a wider range of therapeutic options.METHODS: This prospective study of 109 patients investigated 44 single nucleotide polymorphisms (SNPs) within the susceptibility loci potentially related to coronary artery disease, carotid artery intima-media thickness (cIMT), and in nitric oxide synthase gene. Genotyping was done by the Fluidigm SNP Type assays and Fluidigm 48.48 Dynamic Array IFC. The intima thickness progression (IT) was evaluated by coronary optical coherence tomography (OCT) performed 1 month and 12 months after heart transplantation (HTx).RESULTS: During the first post-HTx year, the mean intima thickness (IT) increased by 24.0 +/- 34.2 mu m (p < 0.001) and lumen area decreased by -0.9 +/- 1.8 mm2 (p < 0.001). The rs1570360 (A/G) SNP of the vascular endothelial growth factor A (VEGFA) gene showed the strongest association with intima thickness progression, even in the presence of the traditional CAV risk factors. SNPs previously related to carotid artery intima-media thickness rs11785239 (PRAG1), rs6584389 (PAX2), rs13225723 (LINC02577) and rs17477177 (CCDC71L), were among the five most significantly associated with IT progression but lost their significance once traditional CAV risk factors had been added.CONCLUSION: Results of this study suggest that genetic variability may play an important role in CAV development. The vascular endothelial growth factor A gene SNP rs1570360 showed the strongest association with intima thickness (IT) progression measured by OCT, even in the presence of the traditional CAV risk factors (Tab. 3, Fig. 3, Ref. 36). Text in PDF www.elis.sk
ER  -

MAYEROVA, Lucie, Anna CHALOUPKA, Peter WOHLFAHRT, Jaroslav Alois HUBACEK, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Ivan MALEK, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Tomas KOVARNIK, Milan SONKA and Michal PAZDERNIK. Role of genetics in the development of cardiac allograft vasculopathy. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2023, vol.~124, No~3, p.~193-200. ISSN~0006-9248. Available from: https://dx.doi.org/10.4149/BLL\_{}2023\_{}031.

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