Chronic venous insufficiency and venous leg ulcers: Aetiology, on the pathophysiology-based treatment

KRIŽANOVÁ, Oľga, Adela PENESOVA, Alica HOKYNKOVÁ, Andrea POKORNÁ, Amir SAMADIAN and Petr BABULA. Chronic venous insufficiency and venous leg ulcers: Aetiology, on the pathophysiology-based treatment. International Wound Journal. Hoboken: Wiley-Blackwell, 2024, vol. 21, No 2, p. 1-9. ISSN 1742-4801. Available from: https://dx.doi.org/10.1111/iwj.14405.

Basic information

• Original name: Chronic venous insufficiency and venous leg ulcers: Aetiology, on the pathophysiology-based treatment
• Authors: KRIŽANOVÁ, Oľga (703 Slovakia, belonging to the institution), Adela PENESOVA (703 Slovakia), Alica HOKYNKOVÁ (703 Slovakia, belonging to the institution), Andrea POKORNÁ (203 Czech Republic, belonging to the institution), Amir SAMADIAN (364 Islamic Republic of Iran, belonging to the institution) and Petr BABULA (203 Czech Republic, guarantor, belonging to the institution).
• Edition: International Wound Journal, Hoboken, Wiley-Blackwell, 2024, 1742-4801.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30216 Dermatology and venereal diseases
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.100 in 2022
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/iwj.14405
• UT WoS: 001085543900001
• Keywords in English: chronic venous insufficiency; compression therapy; therapy; venous leg ulcers; wound coverage
• Tags: 14110229, 14110515, 14110611, rivok
• Tags: International impact, Reviewed

Abstract

The chronic venous disease covers a wide spectrum of venous disorders that are characterized by severely impaired blood return that primarily affects veins in the lower extremities. Morphological and functional abnormalities of the venous system led to chronic venous insufficiency (CVI), and present as leg heaviness/achiness, edema, telangiectasia, and varices. The term 'chronic venous insufficiency' (CVI) refers to a disease of greater severity. Venous dysfunction is associated with venous hypertension and is associated with venous reflux due to poorly functioning or incompetent venous valves, which ultimately reduces venous return, leading to a cascade of morphological, physiological, and histologic abnormalities such as blood pooling, hypoxia, inflammation, swelling, skin changes (lipodermatosclerosis), and in severe cases, venous leg ulcers (VLU). This review summarizes recent knowledge about the aetiology, risk factors, and pathophysiology of VLU and compared the possibilities of their treatment.

Links

• NU21-09-00541, research and development project: Name: Role oxidativního stresu při hojení dekubitů u pacientů s míšní lézí

Investor: Ministry of Health of the CR, Subprogram 1 - standard