The Use of Medical Grade Honey on Infected Chronic Diabetic
Foot Ulcers-A Prospective Case-Control Study

J 2023

The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study

HOLUBOVA, Adela, Lucie CHLUPACOVA, Jitka KROCOVA, Lada CETLOVA, Linsey J F PETERS et. al.

Basic information

Original name

The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study

Authors

HOLUBOVA, Adela (203 Czech Republic), Lucie CHLUPACOVA (203 Czech Republic), Jitka KROCOVA (203 Czech Republic), Lada CETLOVA (203 Czech Republic), Linsey J F PETERS (528 Netherlands), Niels A J CREMERS (528 Netherlands) and Andrea POKORNÁ (203 Czech Republic, belonging to the institution)

Edition

Antibiotics-Basel, BASEL, MDPI, 2023, 2079-6382

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30307 Nursing

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.800 in 2022

RIV identification code

RIV/00216224:14110/23:00132218

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/antibiotics12091364

UT WoS

001071367300001

Keywords in English

medical grade honey; diabetic foot ulcer; diabetes; anti-inflammatory treatment; glycaemia

Abstract

V originále

Non-healing wounds are usually colonised and contaminated by different types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical grade honey (MGH). MGH has antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory features. This study aims to evaluate the effect of MGH therapy on infected non-healing wounds, especially for diabetic foot syndrome. Prospective, observational case series (n = 5) of patients with wounds of diabetic foot syndrome are presented. There were five males with an average age of 61.6 years. All wounds were treated with MGH, and the healing trajectory was rigorously and objectively monitored. In all cases, there was a gradual disappearance of odour, pain, and exudation. Moreover, the wound areas significantly reduced within 40 days and there was a decrease in glycated haemoglobin and glycaemia values. All these outcomes resulted in improved quality of life of the patients. Despite bacterial colonisation, antibiotic treatment was not necessary. All wounds were completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in diabetic foot syndrome wounds, does not increase glycated haemoglobin or glycaemia levels, and thus constitutes an effective alternative to the use of antibiotics in the treatment of locally infected wounds.

Citovat

HOLUBOVA, Adela, Lucie CHLUPACOVA, Jitka KROCOVA, Lada CETLOVA, Linsey J F PETERS, Niels A J CREMERS and Andrea POKORNÁ. The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study. Antibiotics-Basel. BASEL: MDPI, 2023, vol. 12, No 9, p. 1-18. ISSN 2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12091364.

@article{2338643,
   author = {Holubova, Adela and Chlupacova, Lucie and Krocova, Jitka and Cetlova, Lada and Peters, Linsey J F and Cremers, Niels A J and Pokorná, Andrea},
   article_location = {BASEL},
   article_number = {9},
   doi = {http://dx.doi.org/10.3390/antibiotics12091364},
   keywords = {medical grade honey; diabetic foot ulcer; diabetes; anti-inflammatory treatment; glycaemia},
   language = {eng},
   issn = {2079-6382},
   journal = {Antibiotics-Basel},
   title = {The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study},
   url = {https://www.mdpi.com/2079-6382/12/9/1364},
   volume = {12},
   year = {2023}
}

TY  - JOUR
ID  - 2338643
AU  - Holubova, Adela - Chlupacova, Lucie - Krocova, Jitka - Cetlova, Lada - Peters, Linsey J F - Cremers, Niels A J - Pokorná, Andrea
PY  - 2023
TI  - The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study
JF  - Antibiotics-Basel
VL  - 12
IS  - 9
SP  - 1-18
EP  - 1-18
PB  - MDPI
SN  - 20796382
KW  - medical grade honey
KW  - diabetic foot ulcer
KW  - diabetes
KW  - anti-inflammatory treatment
KW  - glycaemia
UR  - https://www.mdpi.com/2079-6382/12/9/1364
N2  - Non-healing wounds are usually colonised and contaminated by different types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical grade honey (MGH). MGH has antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory features. This study aims to evaluate the effect of MGH therapy on infected non-healing wounds, especially for diabetic foot syndrome. Prospective, observational case series (n = 5) of patients with wounds of diabetic foot syndrome are presented. There were five males with an average age of 61.6 years. All wounds were treated with MGH, and the healing trajectory was rigorously and objectively monitored. In all cases, there was a gradual disappearance of odour, pain, and exudation. Moreover, the wound areas significantly reduced within 40 days and there was a decrease in glycated haemoglobin and glycaemia values. All these outcomes resulted in improved quality of life of the patients. Despite bacterial colonisation, antibiotic treatment was not necessary. All wounds were completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in diabetic foot syndrome wounds, does not increase glycated haemoglobin or glycaemia levels, and thus constitutes an effective alternative to the use of antibiotics in the treatment of locally infected wounds.
ER  -

HOLUBOVA, Adela, Lucie CHLUPACOVA, Jitka KROCOVA, Lada CETLOVA, Linsey J F PETERS, Niels A J CREMERS and Andrea POKORNÁ. The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study. \textit{Antibiotics-Basel}. BASEL: MDPI, 2023, vol.~12, No~9, p.~1-18. ISSN~2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12091364.

Detailed Information on Publication Record