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@article{2338643,
author = {Holubova, Adela and Chlupacova, Lucie and Krocova, Jitka and Cetlova, Lada and Peters, Linsey J F and Cremers, Niels A J and Pokorná, Andrea},
article_location = {BASEL},
article_number = {9},
doi = {http://dx.doi.org/10.3390/antibiotics12091364},
keywords = {medical grade honey; diabetic foot ulcer; diabetes; anti-inflammatory treatment; glycaemia},
language = {eng},
issn = {2079-6382},
journal = {Antibiotics-Basel},
title = {The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study},
url = {https://www.mdpi.com/2079-6382/12/9/1364},
volume = {12},
year = {2023}
}
TY - JOUR
ID - 2338643
AU - Holubova, Adela - Chlupacova, Lucie - Krocova, Jitka - Cetlova, Lada - Peters, Linsey J F - Cremers, Niels A J - Pokorná, Andrea
PY - 2023
TI - The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study
JF - Antibiotics-Basel
VL - 12
IS - 9
SP - 1-18
EP - 1-18
PB - MDPI
SN - 20796382
KW - medical grade honey
KW - diabetic foot ulcer
KW - diabetes
KW - anti-inflammatory treatment
KW - glycaemia
UR - https://www.mdpi.com/2079-6382/12/9/1364
N2 - Non-healing wounds are usually colonised and contaminated by different types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical grade honey (MGH). MGH has antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory features. This study aims to evaluate the effect of MGH therapy on infected non-healing wounds, especially for diabetic foot syndrome. Prospective, observational case series (n = 5) of patients with wounds of diabetic foot syndrome are presented. There were five males with an average age of 61.6 years. All wounds were treated with MGH, and the healing trajectory was rigorously and objectively monitored. In all cases, there was a gradual disappearance of odour, pain, and exudation. Moreover, the wound areas significantly reduced within 40 days and there was a decrease in glycated haemoglobin and glycaemia values. All these outcomes resulted in improved quality of life of the patients. Despite bacterial colonisation, antibiotic treatment was not necessary. All wounds were completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in diabetic foot syndrome wounds, does not increase glycated haemoglobin or glycaemia levels, and thus constitutes an effective alternative to the use of antibiotics in the treatment of locally infected wounds.
ER -
HOLUBOVA, Adela, Lucie CHLUPACOVA, Jitka KROCOVA, Lada CETLOVA, Linsey J F PETERS, Niels A J CREMERS and Andrea POKORNÁ. The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study. \textit{Antibiotics-Basel}. BASEL: MDPI, 2023, vol.~12, No~9, p.~1-18. ISSN~2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12091364.
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