OTEVŘEL, Jan. Developing Organocatalysts For Enantioselective Aldol-Type Reactions. In Quo Vadis Chemie? Cyklus přednášek k aktuálním tématům v chemii pořádaný chemickou sekcí PřF UK Praha. 2023.
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Basic information
Original name Developing Organocatalysts For Enantioselective Aldol-Type Reactions
Name in Czech Vývoj organokatalyzátorů pro enantioselektivní reakce aldolového typu
Authors OTEVŘEL, Jan (203 Czech Republic, guarantor, belonging to the institution).
Edition Quo Vadis Chemie? Cyklus přednášek k aktuálním tématům v chemii pořádaný chemickou sekcí PřF UK Praha. 2023.
Other information
Original language English
Type of outcome Requested lectures
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14160/23:00132223
Organization unit Faculty of Pharmacy
Keywords (in Czech) Enantioselectivní organokatalýza; Reakce aldolového typu
Keywords in English Enantioselective Organocatalysis; Aldol-Type Reactions
Tags rivok, ÚChL
Changed by Changed by: PharmDr. Jan Otevřel, Ph.D., učo 245410. Changed: 30/11/2023 13:19.
Abstract
From a broader perspective, aldol-type reactions encompass a plethora of fundamental chemical transformations embodied by the addition of compounds with active hydrogen to molecules bearing a carbonyl or extended carbonyl functionality. Despite the relative attractiveness of chiral aldol units for the construction of bioactive scaffolds, performing these reactions in an enantioselective fashion and downstream chemistry of enantioenriched aldol adducts are both far from trivial. Most products are prone to retro-aldol cleavage and elimination, resulting in a possible undesired epimerization or dehydration during isolation or a subsequent reaction sequence. Furthermore, lower aliphatic aldehydes are gases or low-boiling liquids requiring special procedures for handling. The above aspects represented just a fraction of the challenges to achieving high enantioselectivity for aldol-type processes while developing and screening chiral bifunctional hydrogen bond donor organocatalysts in our group.
Links
MUNI/A/1096/2022, interní kód MUName: Vývoj asymetrické Mannichovy reakce 2-sukcinimidyl, 2-glutarimidyl karboxylátů a příbuzných sloučenin
Investor: Masaryk University
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