Salicylanilides and Their Anticancer Properties

KAUEROVÁ, Tereza, Maria-Jesus PEREZ-PEREZ and Peter KOLLÁR. Salicylanilides and Their Anticancer Properties. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2023, vol. 24, No 2, p. 1-22. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms24021728.

Basic information

• Original name: Salicylanilides and Their Anticancer Properties
• Authors: KAUEROVÁ, Tereza (203 Czech Republic, belonging to the institution), Maria-Jesus PEREZ-PEREZ and Peter KOLLÁR (203 Czech Republic, guarantor, belonging to the institution).
• Edition: International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2023, 1422-0067.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 5.600 in 2022
• RIV identification code: RIV/00216224:14160/23:00132228
• Organization unit: Faculty of Pharmacy
• Doi: http://dx.doi.org/10.3390/ijms24021728
• UT WoS: 000914982800001
• Keywords in English: salicylanilides; anticancer properties; mitochondrial uncoupling; TK EGFR; STAT3; drug repurposing; niclosamide
• Tags: rivok, ÚFTo
• Tags: International impact, Reviewed

Abstract

Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most likely by diverse mechanisms of action such as uncoupling of oxidative phosphorylation, inhibition of protein tyrosine kinase epidermal growth factor receptor, modulation of different signaling pathways as Wnt/beta-catenin, mTORC1, STAT3, NF-kappa B and Notch signaling pathways or induction of B-Raf V600E inhibition. Here we provide a comprehensive overview of the current knowledge about the proposed mechanisms of action of anticancer activity of salicylanilides based on preclinical in vitro and in vivo studies, or structural requirements for such an activity.