Salicylanilides and Their Anticancer Properties

J 2023

Salicylanilides and Their Anticancer Properties

KAUEROVÁ, Tereza, Maria-Jesus PEREZ-PEREZ and Peter KOLLÁR

Basic information

Original name

Salicylanilides and Their Anticancer Properties

Authors

KAUEROVÁ, Tereza (203 Czech Republic, belonging to the institution), Maria-Jesus PEREZ-PEREZ and Peter KOLLÁR (203 Czech Republic, guarantor, belonging to the institution)

Edition

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2023, 1422-0067

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.600 in 2022

RIV identification code

RIV/00216224:14160/23:00132228

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/ijms24021728

UT WoS

000914982800001

Keywords in English

salicylanilides; anticancer properties; mitochondrial uncoupling; TK EGFR; STAT3; drug repurposing; niclosamide

Abstract

V originále

Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most likely by diverse mechanisms of action such as uncoupling of oxidative phosphorylation, inhibition of protein tyrosine kinase epidermal growth factor receptor, modulation of different signaling pathways as Wnt/beta-catenin, mTORC1, STAT3, NF-kappa B and Notch signaling pathways or induction of B-Raf V600E inhibition. Here we provide a comprehensive overview of the current knowledge about the proposed mechanisms of action of anticancer activity of salicylanilides based on preclinical in vitro and in vivo studies, or structural requirements for such an activity.

Citovat

KAUEROVÁ, Tereza, Maria-Jesus PEREZ-PEREZ and Peter KOLLÁR. Salicylanilides and Their Anticancer Properties. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2023, vol. 24, No 2, p. 1-22. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms24021728.

@article{2339086,
   author = {Kauerová, Tereza and PerezandPerez, MariaandJesus and Kollár, Peter},
   article_location = {Basel},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/ijms24021728},
   keywords = {salicylanilides; anticancer properties; mitochondrial uncoupling; TK EGFR; STAT3; drug repurposing; niclosamide},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Salicylanilides and Their Anticancer Properties},
   url = {https://www.mdpi.com/1422-0067/24/2/1728},
   volume = {24},
   year = {2023}
}

TY  - JOUR
ID  - 2339086
AU  - Kauerová, Tereza - Perez-Perez, Maria-Jesus - Kollár, Peter
PY  - 2023
TI  - Salicylanilides and Their Anticancer Properties
JF  - International Journal of Molecular Sciences
VL  - 24
IS  - 2
SP  - 1-22
EP  - 1-22
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - salicylanilides
KW  - anticancer properties
KW  - mitochondrial uncoupling
KW  - TK EGFR
KW  - STAT3
KW  - drug repurposing
KW  - niclosamide
UR  - https://www.mdpi.com/1422-0067/24/2/1728
N2  - Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most likely by diverse mechanisms of action such as uncoupling of oxidative phosphorylation, inhibition of protein tyrosine kinase epidermal growth factor receptor, modulation of different signaling pathways as Wnt/beta-catenin, mTORC1, STAT3, NF-kappa B and Notch signaling pathways or induction of B-Raf V600E inhibition. Here we provide a comprehensive overview of the current knowledge about the proposed mechanisms of action of anticancer activity of salicylanilides based on preclinical in vitro and in vivo studies, or structural requirements for such an activity.
ER  -

KAUEROVÁ, Tereza, Maria-Jesus PEREZ-PEREZ and Peter KOLLÁR. Salicylanilides and Their Anticancer Properties. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2023, vol.~24, No~2, p.~1-22. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms24021728.

Detailed Information on Publication Record