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@article{2339097, author = {Malaník, Milan and Čulenová, Marie and Sychrová, Alice and Skiba, Adrianna and SkalickaandWozniak, Krystyna and Šmejkal, Karel}, article_location = {BASEL}, article_number = {8}, doi = {http://dx.doi.org/10.3390/ph16081061}, keywords = {epilepsy; anticonvulsant; natural products; GABA; AMPA; NMDA}, language = {eng}, issn = {1424-8247}, journal = {PHARMACEUTICALS}, title = {Treating Epilepsy with Natural Products: Nonsense or Possibility?}, url = {https://www.mdpi.com/1424-8247/16/8/1061}, volume = {16}, year = {2023} }
TY - JOUR ID - 2339097 AU - Malaník, Milan - Čulenová, Marie - Sychrová, Alice - Skiba, Adrianna - Skalicka-Wozniak, Krystyna - Šmejkal, Karel PY - 2023 TI - Treating Epilepsy with Natural Products: Nonsense or Possibility? JF - PHARMACEUTICALS VL - 16 IS - 8 SP - 1-22 EP - 1-22 PB - MDPI SN - 14248247 KW - epilepsy KW - anticonvulsant KW - natural products KW - GABA KW - AMPA KW - NMDA UR - https://www.mdpi.com/1424-8247/16/8/1061 N2 - Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness. Although modern medicine has effective antiepileptic drugs, the need for accessible and cost-effective medication is urgent, and products derived from plants could offer a solution. For this review, we have focused on natural compounds that have shown anticonvulsant activity in in vivo models of epilepsy at relevant doses. In some cases, the effects have been confirmed by clinical data. The results of our search are summarized in tables according to their molecular targets. We have critically evaluated the data we present, identified the most promising therapeutic candidates, and discussed these in the text. Their perspectives are supported by both pharmacokinetic properties and potential interactions. This review is intended to serve as a basis for future research into epilepsy and related disorders. ER -
MALANÍK, Milan, Marie ČULENOVÁ, Alice SYCHROVÁ, Adrianna SKIBA, Krystyna SKALICKA-WOZNIAK and Karel ŠMEJKAL. Treating Epilepsy with Natural Products: Nonsense or Possibility? \textit{PHARMACEUTICALS}. BASEL: MDPI, 2023, vol.~16, No~8, p.~1-22. ISSN~1424-8247. Available from: https://dx.doi.org/10.3390/ph16081061.
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