GUERRA-SLOMPO, Eloise Pavao, Gisele Fernanda Assine PICCHI-CONSTANTE, Martin MAREK, Christophe ROMIER, Wolfgang SIPPL a Nilson Ivo Tonin ZANCHIN. In cellulo and in vivo assays for compound testing against Trypanosoma cruzi. STAR Protocols. United States: Cell Press, 2023, roč. 4, č. 1, s. 1-42. ISSN 2666-1667. Dostupné z: https://dx.doi.org/10.1016/j.xpro.2023.102058. |
Další formáty:
BibTeX
LaTeX
RIS
@article{2339437, author = {GuerraandSlompo, Eloise Pavao and PicchiandConstante, Gisele Fernanda Assine and Marek, Martin and Romier, Christophe and Sippl, Wolfgang and Zanchin, Nilson Ivo Tonin}, article_location = {United States}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.xpro.2023.102058}, keywords = {Cell Biology; Cell-based Assays; High-throughput Screening; Microbiology; Model Organisms}, language = {eng}, issn = {2666-1667}, journal = {STAR Protocols}, title = {In cellulo and in vivo assays for compound testing against Trypanosoma cruzi}, url = {https://www.sciencedirect.com/science/article/pii/S2666166723000163?via%3Dihub}, volume = {4}, year = {2023} }
TY - JOUR ID - 2339437 AU - Guerra-Slompo, Eloise Pavao - Picchi-Constante, Gisele Fernanda Assine - Marek, Martin - Romier, Christophe - Sippl, Wolfgang - Zanchin, Nilson Ivo Tonin PY - 2023 TI - In cellulo and in vivo assays for compound testing against Trypanosoma cruzi JF - STAR Protocols VL - 4 IS - 1 SP - 1-42 EP - 1-42 PB - Cell Press SN - 26661667 KW - Cell Biology KW - Cell-based Assays KW - High-throughput Screening KW - Microbiology KW - Model Organisms UR - https://www.sciencedirect.com/science/article/pii/S2666166723000163?via%3Dihub N2 - Here, we describe a combined in cellulo and in vivo approach to identify com-pounds with higher potential for efficient inhibition of Trypanosoma cruzi. Phase I of in cellulo assays is designed to exclude inactive or toxic compounds, while phase II is designed for accurate IC50, CC50, and selective index (SI) determina-tion. Compounds showing high SI are tested using in vivo infection models in par-allel with benznidazole to assess their efficacy relative to a reference drug used for Chagas disease treatment. For complete details on the use and execution of this protocol, please refer to Marek et al. (2021).1 ER -
GUERRA-SLOMPO, Eloise Pavao, Gisele Fernanda Assine PICCHI-CONSTANTE, Martin MAREK, Christophe ROMIER, Wolfgang SIPPL a Nilson Ivo Tonin ZANCHIN. In cellulo and in vivo assays for compound testing against Trypanosoma cruzi. \textit{STAR Protocols}. United States: Cell Press, 2023, roč.~4, č.~1, s.~1-42. ISSN~2666-1667. Dostupné z: https://dx.doi.org/10.1016/j.xpro.2023.102058.
|