Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

STANÍKOVÁ, Andrea, Martin JOUZA, Júlia BOHOŠOVÁ, Ondřej SLABÝ and Petr JABANDŽIEV. Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates. BMJ Paediatrics Open. LONDON: BMJ PUBLISHING GROUP, 2023, vol. 7, No 1, p. 1-8. ISSN 2399-9772. Available from: https://dx.doi.org/10.1136/bmjpo-2023-002172.

Basic information

• Original name: Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates
• Authors: STANÍKOVÁ, Andrea (703 Slovakia, belonging to the institution), Martin JOUZA (203 Czech Republic, belonging to the institution), Júlia BOHOŠOVÁ (703 Slovakia, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Petr JABANDŽIEV (203 Czech Republic, guarantor, belonging to the institution).
• Edition: BMJ Paediatrics Open, LONDON, BMJ PUBLISHING GROUP, 2023, 2399-9772.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30209 Paediatrics
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.600 in 2022
• RIV identification code: RIV/00216224:14110/23:00132253
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1136/bmjpo-2023-002172
• UT WoS: 001099840500001
• Keywords in English: microbiome; necrotising enterocolitis; preterm neonates
• Tags: 14110317, 14110513, podil, rivok
• Tags: International impact, Reviewed

Abstract

Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC’s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it.