Role of the microbiome in pathophysiology of necrotising
enterocolitis in preterm neonates

J 2023

Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

STANÍKOVÁ, Andrea, Martin JOUZA, Júlia BOHOŠOVÁ, Ondřej SLABÝ, Petr JABANDŽIEV et. al.

Basic information

Original name

Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

Authors

STANÍKOVÁ, Andrea (703 Slovakia, belonging to the institution), Martin JOUZA (203 Czech Republic, belonging to the institution), Júlia BOHOŠOVÁ (703 Slovakia, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Petr JABANDŽIEV (203 Czech Republic, guarantor, belonging to the institution)

Edition

BMJ Paediatrics Open, LONDON, BMJ PUBLISHING GROUP, 2023, 2399-9772

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30209 Paediatrics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.600 in 2022

RIV identification code

RIV/00216224:14110/23:00132253

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1136/bmjpo-2023-002172

UT WoS

001099840500001

Keywords in English

microbiome; necrotising enterocolitis; preterm neonates

Abstract

V originále

Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC’s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it.

Citovat

STANÍKOVÁ, Andrea, Martin JOUZA, Júlia BOHOŠOVÁ, Ondřej SLABÝ and Petr JABANDŽIEV. Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates. BMJ Paediatrics Open. LONDON: BMJ PUBLISHING GROUP, 2023, vol. 7, No 1, p. 1-8. ISSN 2399-9772. Available from: https://dx.doi.org/10.1136/bmjpo-2023-002172.

@article{2339478,
   author = {Staníková, Andrea and Jouza, Martin and Bohošová, Júlia and Slabý, Ondřej and Jabandžiev, Petr},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1136/bmjpo-2023-002172},
   keywords = {microbiome; necrotising enterocolitis; preterm neonates},
   language = {eng},
   issn = {2399-9772},
   journal = {BMJ Paediatrics Open},
   title = {Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates},
   url = {https://bmjpaedsopen.bmj.com/content/7/1/e002172},
   volume = {7},
   year = {2023}
}

TY  - JOUR
ID  - 2339478
AU  - Staníková, Andrea - Jouza, Martin - Bohošová, Júlia - Slabý, Ondřej - Jabandžiev, Petr
PY  - 2023
TI  - Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates
JF  - BMJ Paediatrics Open
VL  - 7
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - BMJ PUBLISHING GROUP
SN  - 23999772
KW  - microbiome
KW  - necrotising enterocolitis
KW  - preterm neonates
UR  - https://bmjpaedsopen.bmj.com/content/7/1/e002172
N2  - Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC’s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it.
ER  -

STANÍKOVÁ, Andrea, Martin JOUZA, Júlia BOHOŠOVÁ, Ondřej SLABÝ and Petr JABANDŽIEV. Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates. \textit{BMJ Paediatrics Open}. LONDON: BMJ PUBLISHING GROUP, 2023, vol.~7, No~1, p.~1-8. ISSN~2399-9772. Available from: https://dx.doi.org/10.1136/bmjpo-2023-002172.

Detailed Information on Publication Record