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@article{2339561,
author = {Cassani, Marco and Fernandes, Soraia and Cruz, Jorge OliverandDe La and Durikova, Helena and Vrbsky, Jan and Patočka, Marek and Hegrova, Veronika and Klimovič, Šimon and Přibyl, Jan and Debellis, Doriana and Skládal, Petr and Cavalieri, Francesca and Caruso, Frank and Forte, Giancarlo},
article_number = {2},
doi = {http://dx.doi.org/10.1002/advs.202302965},
keywords = {cell-nanoparticle interactions; nanotherapies; yes-associated protein; breast cancer},
language = {eng},
issn = {2198-3844},
journal = {Advanced Science},
title = {YAP Signaling Regulates the Cellular Uptake and Therapeutic Effect of Nanoparticles},
url = {https://doi.org/10.1002/advs.202302965},
volume = {11},
year = {2024}
}
TY - JOUR
ID - 2339561
AU - Cassani, Marco - Fernandes, Soraia - Cruz, Jorge Oliver-De La - Durikova, Helena - Vrbsky, Jan - Patočka, Marek - Hegrova, Veronika - Klimovič, Šimon - Přibyl, Jan - Debellis, Doriana - Skládal, Petr - Cavalieri, Francesca - Caruso, Frank - Forte, Giancarlo
PY - 2024
TI - YAP Signaling Regulates the Cellular Uptake and Therapeutic Effect of Nanoparticles
JF - Advanced Science
VL - 11
IS - 2
SP - 1-16
EP - 1-16
PB - Wiley-VCH GmbH
SN - 21983844
KW - cell-nanoparticle interactions
KW - nanotherapies
KW - yes-associated protein
KW - breast cancer
UR - https://doi.org/10.1002/advs.202302965
N2 - Interactions between living cells and nanoparticles are extensively studied to enhance the delivery of therapeutics. Nanoparticles size, shape, stiffness, and surface charge are regarded as the main features able to control the fate of cell-nanoparticle interactions. However, the clinical translation of nanotherapies has so far been limited, and there is a need to better understand the biology of cell-nanoparticle interactions. This study investigates the role of cellular mechanosensitive components in cell-nanoparticle interactions. It is demonstrated that the genetic and pharmacologic inhibition of yes-associated protein (YAP), a key component of cancer cell mechanosensing apparatus and Hippo pathway effector, improves nanoparticle internalization in triple-negative breast cancer cells regardless of nanoparticle properties or substrate characteristics. This process occurs through YAP-dependent regulation of endocytic pathways, cell mechanics, and membrane organization. Hence, the study proposes targeting YAP may sensitize triple-negative breast cancer cells to chemotherapy and increase the selectivity of nanotherapy.
ER -
CASSANI, Marco, Soraia FERNANDES, Jorge Oliver-De La CRUZ, Helena DURIKOVA, Jan VRBSKY, Marek PATOČKA, Veronika HEGROVA, Šimon KLIMOVIČ, Jan PŘIBYL, Doriana DEBELLIS, Petr SKLÁDAL, Francesca CAVALIERI, Frank CARUSO and Giancarlo FORTE. YAP Signaling Regulates the Cellular Uptake and Therapeutic Effect of Nanoparticles. \textit{Advanced Science}. Wiley-VCH GmbH, 2024, vol.~11, No~2, p.~1-16. ISSN~2198-3844. Available from: https://dx.doi.org/10.1002/advs.202302965.
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