WEISS, Viktor, Pavel ŘÍHA, Irena DOLEŽALOVÁ, Martin KOJAN, Vladimír ČERVEŇÁK, Julius SIMKO, Roman HERZIG and Ivan REKTOR. Brain Areas Predisposing to the Stroke-Related Epilepsy Development. Acta Neurologica Scandinavica. MALDEN: WILEY-BLACKWELL, 2023, vol. 2023, August 2023, p. 1-6. ISSN 0001-6314. Available from: https://dx.doi.org/10.1155/2023/1439121.
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Basic information
Original name Brain Areas Predisposing to the Stroke-Related Epilepsy Development
Authors WEISS, Viktor (203 Czech Republic, belonging to the institution), Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Martin KOJAN (703 Slovakia, belonging to the institution), Vladimír ČERVEŇÁK (203 Czech Republic, belonging to the institution), Julius SIMKO (203 Czech Republic), Roman HERZIG (203 Czech Republic) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution).
Edition Acta Neurologica Scandinavica, MALDEN, WILEY-BLACKWELL, 2023, 0001-6314.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.500 in 2022
RIV identification code RIV/00216224:14110/23:00134674
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1155/2023/1439121
UT WoS 001057498800001
Keywords in English stroke-related epilepsy; brain; ischemia;
Tags 14110119, 14110127, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Dubská, učo 77638. Changed: 15/2/2024 21:37.
Abstract
Background. Stroke-related epilepsy (STRE) represents a significant health problem. We focused on identifying brain areas, which involvement in ischemia predisposes a patient to STRE development. Methods. We retrospectively identified a group of patients with STRE consisting of 33 subjects. Subsequently, age-, sex-, and territory-matched controls who underwent stroke but did not develop STRE (control group (CG)) were identified. The CG was composed of 37 patients. The total ischemia volume and distribution of ischemic changes were compared between STRE and CG. We also analyzed multivariate statistics to identify independent variables predisposing to STRE development. Results. The patients with STRE exhibited a bigger volume of ischemia than CG (average volume of ischemia in STRE 60.8 cm3, in CG 42.4 cm3, p=0.029). When comparing STRE and CG, there were differences in the distribution of ischemic changes in the temporal lobe (transverse (Heschl's) temporal gyri, superior temporal gyrus, and middle temporal gyrus) and parietooccipital region (postcentral gyrus, supramarginal gyrus, angular gyrus, parietal operculum, lingual gyrus, and superior occipital gyrus). The involvement of transverse temporal (Heschl's) gyri (p=0.0222, odds ratio 30.0767), age (p=0.0110, odds ratio 1.0745), and SeLECT score (p=0.0480, odds ratio 1.8682) were identified as independent predictors for STRE development. Conclusion. The higher volume of ischemia correlates with a higher risk of STRE development. Some areas, particularly in the temporal and parietal neocortex, predispose the brain to generate epilepsy after the stroke.
Links
NU21-04-00254, research and development projectName: Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování (Acronym: MultiEPI)
Investor: Ministry of Health of the CR, Detection of seizure onset zone in multi-lesional epilepsies using multimodal imaging methods, Subprogram 1 - standard
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