Laser Ablation Inductively Coupled Plasma Mass Spectrometry as
a Powerful Tool for Spatially Resolved Analysis: An Experiment
for Undergraduate Analytical Chemistry Laboratory

J 2023

Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory

KUCHYNKA, Michaela, Hana HOLCOVÁ POLANSKÁ, Jaromír GUMULEC, Viktor KANICKÝ, Tomáš VACULOVIČ et. al.

Basic information

Original name

Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory

Authors

KUCHYNKA, Michaela (203 Czech Republic, guarantor, belonging to the institution), Hana HOLCOVÁ POLANSKÁ (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Viktor KANICKÝ (203 Czech Republic, belonging to the institution) and Tomáš VACULOVIČ (203 Czech Republic, belonging to the institution)

Edition

Journal of Chemical Education, WASHINGTON, American Chemical Society, 2023, 0021-9584

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.000 in 2022

RIV identification code

RIV/00216224:14310/23:00132316

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1021/acs.jchemed.2c01111

UT WoS

000979469700001

Keywords in English

Upper-Division Undergraduate; Analytical Chemistry; Lasers; Mass Spectrometry; Quantitative Analysis

Abstract

V originále

A new experiment using laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate students. While most analytical methods only provide information on the amount of the analyte, LA-ICP-MS allows extra information on the distribution of the element in the sample. Because it achieves excellent limits of detection (sub mu g center dot g-1) and high spatial resolution (micrometer scale), it is a powerful technique for imaging any sample. A thin section of mouse tissue was used as a model sample to demonstrate these abilities. The student's task was to determine the distribution of the essential elements Zn, Cu, and Pt (Pt introduced into the tumor tissue from the cytostatic drug (cis Pt)) and quantify their amount.

Links

MUNI/R/1568/2020, interní kód MU

Name: Study the effectiveness of anticancer drugs (Acronym: STEAD)

Investor: Masaryk University, CAREER RESTART

Citovat

KUCHYNKA, Michaela, Hana HOLCOVÁ POLANSKÁ, Jaromír GUMULEC, Viktor KANICKÝ and Tomáš VACULOVIČ. Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory. Journal of Chemical Education. WASHINGTON: American Chemical Society, 2023, vol. 100, No 5, p. 1973-1979. ISSN 0021-9584. Available from: https://dx.doi.org/10.1021/acs.jchemed.2c01111.

@article{2341300,
   author = {Kuchynka, Michaela and Holcová Polanská, Hana and Gumulec, Jaromír and Kanický, Viktor and Vaculovič, Tomáš},
   article_location = {WASHINGTON},
   article_number = {5},
   doi = {http://dx.doi.org/10.1021/acs.jchemed.2c01111},
   keywords = {Upper-Division Undergraduate; Analytical Chemistry; Lasers; Mass Spectrometry; Quantitative Analysis},
   language = {eng},
   issn = {0021-9584},
   journal = {Journal of Chemical Education},
   title = {Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory},
   url = {https://pubs.acs.org/doi/10.1021/acs.jchemed.2c01111},
   volume = {100},
   year = {2023}
}

TY  - JOUR
ID  - 2341300
AU  - Kuchynka, Michaela - Holcová Polanská, Hana - Gumulec, Jaromír - Kanický, Viktor - Vaculovič, Tomáš
PY  - 2023
TI  - Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory
JF  - Journal of Chemical Education
VL  - 100
IS  - 5
SP  - 1973-1979
EP  - 1973-1979
PB  - American Chemical Society
SN  - 00219584
KW  - Upper-Division Undergraduate
KW  - Analytical Chemistry
KW  - Lasers
KW  - Mass Spectrometry
KW  - Quantitative Analysis
UR  - https://pubs.acs.org/doi/10.1021/acs.jchemed.2c01111
N2  - A new experiment using laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate students. While most analytical methods only provide information on the amount of the analyte, LA-ICP-MS allows extra information on the distribution of the element in the sample. Because it achieves excellent limits of detection (sub mu g center dot g-1) and high spatial resolution (micrometer scale), it is a powerful technique for imaging any sample. A thin section of mouse tissue was used as a model sample to demonstrate these abilities. The student's task was to determine the distribution of the essential elements Zn, Cu, and Pt (Pt introduced into the tumor tissue from the cytostatic drug (cis Pt)) and quantify their amount.
ER  -

KUCHYNKA, Michaela, Hana HOLCOVÁ POLANSKÁ, Jaromír GUMULEC, Viktor KANICKÝ and Tomáš VACULOVIČ. Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory. \textit{Journal of Chemical Education}. WASHINGTON: American Chemical Society, 2023, vol.~100, No~5, p.~1973-1979. ISSN~0021-9584. Available from: https://dx.doi.org/10.1021/acs.jchemed.2c01111.

Detailed Information on Publication Record