Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR)
play both distinct and common roles in the regulation of colon
homeostasis and intestinal carcinogenesis

J 2023

Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis

VÁZQUEZ GÓMEZ, Gerardo, Jiří PETRÁŠ, Zdeněk DVOŘÁK and Jan VONDRÁČEK

Basic information

Original name

Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis

Authors

VÁZQUEZ GÓMEZ, Gerardo (484 Mexico), Jiří PETRÁŠ (203 Czech Republic, belonging to the institution), Zdeněk DVOŘÁK and Jan VONDRÁČEK (203 Czech Republic, guarantor)

Edition

Biochemical Pharmacology, Elsevier, 2023, 0006-2952

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.800 in 2022

RIV identification code

RIV/00216224:14310/23:00132321

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.bcp.2023.115797

UT WoS

001078865300001

Keywords in English

Colon cancer; Aryl hydrocarbon receptor; Pregnane X receptor; Intestine; Microbial agonists; Inflammation; Epithelial barrier; Dietary contaminants

Abstract

V originále

Both aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) belong among key regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a wide range of environmental and dietary carcinogens. The data accumulated over the last two decades suggest that both of these transcriptional regulators play a much wider role in the maintenance of gut homeostasis, and that both transcription factors may affect processes linked with intestinal tumorigenesis. Intestinal epithelium is continuously exposed to a wide range of AhR, PXR and dual AhR/PXR ligands formed by intestinal microbiota or originating from diet. Current evidence suggests that specific ligands of both AhR and PXR can protect intestinal epithelium against inflammation and assist in the maintenance of epithelial barrier integrity. AhR, and to a lesser extent also PXR, have been shown to play a protective role against inflammation-induced colon cancer, or, in mouse models employing overactivation of Wnt/β-catenin signaling. In contrast, other evidence suggests that both receptors may contribute to modulation of transformed colon cell behavior, with a potential to promote cancer progression and/or chemoresistance. The review focuses on both overlapping and separate roles of the two receptors in these processes, and on possible implications of their activity within the context of intestinal tissue.

Citovat

VÁZQUEZ GÓMEZ, Gerardo, Jiří PETRÁŠ, Zdeněk DVOŘÁK and Jan VONDRÁČEK. Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis. Biochemical Pharmacology. Elsevier, 2023, vol. 216, October 2023, p. 1-14. ISSN 0006-2952. Available from: https://dx.doi.org/10.1016/j.bcp.2023.115797.

@article{2341437,
   author = {Vázquez Gómez, Gerardo and Petráš, Jiří and Dvořák, Zdeněk and Vondráček, Jan},
   article_number = {October 2023},
   doi = {http://dx.doi.org/10.1016/j.bcp.2023.115797},
   keywords = {Colon cancer; Aryl hydrocarbon receptor; Pregnane X receptor; Intestine; Microbial agonists; Inflammation; Epithelial barrier; Dietary contaminants},
   language = {eng},
   issn = {0006-2952},
   journal = {Biochemical Pharmacology},
   title = {Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis},
   url = {https://doi.org/10.1016/j.bcp.2023.115797},
   volume = {216},
   year = {2023}
}

TY  - JOUR
ID  - 2341437
AU  - Vázquez Gómez, Gerardo - Petráš, Jiří - Dvořák, Zdeněk - Vondráček, Jan
PY  - 2023
TI  - Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis
JF  - Biochemical Pharmacology
VL  - 216
IS  - October 2023
SP  - 1-14
EP  - 1-14
PB  - Elsevier
SN  - 00062952
KW  - Colon cancer
KW  - Aryl hydrocarbon receptor
KW  - Pregnane X receptor
KW  - Intestine
KW  - Microbial agonists
KW  - Inflammation
KW  - Epithelial barrier
KW  - Dietary contaminants
UR  - https://doi.org/10.1016/j.bcp.2023.115797
N2  - Both aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) belong among key regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a wide range of environmental and dietary carcinogens. The data accumulated over the last two decades suggest that both of these transcriptional regulators play a much wider role in the maintenance of gut homeostasis, and that both transcription factors may affect processes linked with intestinal tumorigenesis. Intestinal epithelium is continuously exposed to a wide range of AhR, PXR and dual AhR/PXR ligands formed by intestinal microbiota or originating from diet. Current evidence suggests that specific ligands of both AhR and PXR can protect intestinal epithelium against inflammation and assist in the maintenance of epithelial barrier integrity. AhR, and to a lesser extent also PXR, have been shown to play a protective role against inflammation-induced colon cancer, or, in mouse models employing overactivation of Wnt/β-catenin signaling. In contrast, other evidence suggests that both receptors may contribute to modulation of transformed colon cell behavior, with a potential to promote cancer progression and/or chemoresistance. The review focuses on both overlapping and separate roles of the two receptors in these processes, and on possible implications of their activity within the context of intestinal tissue.
ER  -

VÁZQUEZ GÓMEZ, Gerardo, Jiří PETRÁŠ, Zdeněk DVOŘÁK and Jan VONDRÁČEK. Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis. \textit{Biochemical Pharmacology}. Elsevier, 2023, vol.~216, October 2023, p.~1-14. ISSN~0006-2952. Available from: https://dx.doi.org/10.1016/j.bcp.2023.115797.

Detailed Information on Publication Record