Novel fluorophores applicable for glycan detection

VESELÝ, Hubert, Hana PÍŽOVÁ and Pavel BOBÁĽ. Novel fluorophores applicable for glycan detection. In CECE 2023. 18th International Interdisciplinary Meeting on Bioanalysis. 2023. 2023.

Basic information

• Original name: Novel fluorophores applicable for glycan detection
• Authors: VESELÝ, Hubert (203 Czech Republic, belonging to the institution), Hana PÍŽOVÁ (203 Czech Republic, belonging to the institution) and Pavel BOBÁĽ (703 Slovakia, belonging to the institution).
• Edition: CECE 2023. 18th International Interdisciplinary Meeting on Bioanalysis. 2023, 2023.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14160/23:00132382
• Organization unit: Faculty of Pharmacy
• Keywords in English: fluorophore; pyrrole; glycan
• Tags: rivok, ÚChL

Abstract

Changes in the composition of glycans correlate with the progression of many diseases; therefore, they are investigated as disease markers. Unfortunately, their analysis is complicated because they do not contain a chromophore or charges that would enable their electrophoretic separation. Our idea was to develop a new fluorescent marker covalently bound to glycans providing fast labeling kinetics, high quantum yield, increased detection sensitivity using MS, and at the same time, carrying a charge in the structure, which will enable the studied glycans to be separated electrophoretically

Links

• GA22-00236S, research and development project: Name: Vývoj nových fluorescenčních značek pro elektroforetické analýzy glykoproteinů asociovaných s rakovinou prsu (Acronym: 22-00236S)

Investor: Czech Science Foundation