Další formáty:
BibTeX
LaTeX
RIS
@proceedings{2344739, author = {Ballayová, Veronika and Kauerová, Tereza and Kollár, Peter and Farsa, Oldřich}, booktitle = {51st Conference Synthesis and Analysis of Drugs, 2023}, doi = {http://dx.doi.org/10.2478/afpuc-2023-0022}, keywords = {Schiff bases; basic acetophenone derivative; aminopeptidase N; metalloenzyme inhibitor}, language = {eng}, title = {SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS}, year = {2023} }
TY - CONF ID - 2344739 AU - Ballayová, Veronika - Kauerová, Tereza - Kollár, Peter - Farsa, Oldřich PY - 2023 TI - SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS KW - Schiff bases KW - basic acetophenone derivative KW - aminopeptidase N KW - metalloenzyme inhibitor N2 - Basic thiosemicarbazone and semicarbazone derivatives of acetophenone with imine functional group belong to the group commonly called Schiff bases. Therapeutics and compounds belonging to this group are versatile pharmacophores with a significant capability of forming chelates with various metal ions. Such metal complexes play an important role in therapeutics due to their remarkable broad-spectrum of biological activities. Due to the above-mentioned complex formation, many Schiff bases appear as an important intermediate in a number of enzymatic reactions. One of the possible target enzyme is a neutral zinc-binding metalloenzyme aminopeptidase N (AP-N), also called membrane alanyl aminopeptidase. Potential inhibitors of this omnipresent enzyme may offer effective and broad-spectrum therapy. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone. ER -
BALLAYOVÁ, Veronika, Tereza KAUEROVÁ, Peter KOLLÁR a Oldřich FARSA. SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS. In \textit{51st Conference Synthesis and Analysis of Drugs, 2023}. 2023. Dostupné z: https://dx.doi.org/10.2478/afpuc-2023-0022.
|