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@proceedings{2344739,
author = {Ballayová, Veronika and Kauerová, Tereza and Kollár, Peter and Farsa, Oldřich},
booktitle = {51st Conference Synthesis and Analysis of Drugs, 2023},
doi = {http://dx.doi.org/10.2478/afpuc-2023-0022},
keywords = {Schiff bases; basic acetophenone derivative; aminopeptidase N; metalloenzyme inhibitor},
language = {eng},
title = {SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS},
year = {2023}
}
TY - CONF
ID - 2344739
AU - Ballayová, Veronika - Kauerová, Tereza - Kollár, Peter - Farsa, Oldřich
PY - 2023
TI - SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS
KW - Schiff bases
KW - basic acetophenone derivative
KW - aminopeptidase N
KW - metalloenzyme inhibitor
N2 - Basic thiosemicarbazone and semicarbazone derivatives of acetophenone with imine functional group belong to the group commonly called Schiff bases. Therapeutics and compounds belonging to this group are versatile pharmacophores with a significant capability of forming chelates with various metal ions. Such metal complexes play an important role in therapeutics due to their remarkable broad-spectrum of biological activities. Due to the above-mentioned complex formation, many Schiff bases appear as an important intermediate in a number of enzymatic reactions. One of the possible target enzyme is a neutral zinc-binding metalloenzyme aminopeptidase N (AP-N), also called membrane alanyl aminopeptidase. Potential inhibitors of this omnipresent enzyme may offer effective and broad-spectrum therapy. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.
ER -
BALLAYOVÁ, Veronika, Tereza KAUEROVÁ, Peter KOLLÁR and Oldřich FARSA. SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS. In \textit{51st Conference Synthesis and Analysis of Drugs, 2023}. 2023. Available from: https://dx.doi.org/10.2478/afpuc-2023-0022.
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