k 2023

SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS

BALLAYOVÁ, Veronika, Tereza KAUEROVÁ, Peter KOLLÁR and Oldřich FARSA

Basic information

Original name

SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS

Authors

BALLAYOVÁ, Veronika (703 Slovakia, belonging to the institution), Tereza KAUEROVÁ (203 Czech Republic, belonging to the institution), Peter KOLLÁR (203 Czech Republic, belonging to the institution) and Oldřich FARSA (203 Czech Republic, belonging to the institution)

Edition

51st Conference Synthesis and Analysis of Drugs, 2023, 2023

Other information

Language

English

Type of outcome

Prezentace na konferencích

Field of Study

30107 Medicinal chemistry

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14160/23:00132384

Organization unit

Faculty of Pharmacy

DOI

Keywords in English

Schiff bases; basic acetophenone derivative; aminopeptidase N; metalloenzyme inhibitor

Tags

Tags

International impact
Změněno: 5/4/2024 07:48, Mgr. Daniela Černá

Abstract

V originále

Basic thiosemicarbazone and semicarbazone derivatives of acetophenone with imine functional group belong to the group commonly called Schiff bases. Therapeutics and compounds belonging to this group are versatile pharmacophores with a significant capability of forming chelates with various metal ions. Such metal complexes play an important role in therapeutics due to their remarkable broad-spectrum of biological activities. Due to the above-mentioned complex formation, many Schiff bases appear as an important intermediate in a number of enzymatic reactions. One of the possible target enzyme is a neutral zinc-binding metalloenzyme aminopeptidase N (AP-N), also called membrane alanyl aminopeptidase. Potential inhibitors of this omnipresent enzyme may offer effective and broad-spectrum therapy. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.

Links

EF19_073/0016943, research and development project
Name: Interní grantová agentura Masarykovy univerzity
MUNI/A/1682/2020, interní kód MU
Name: Návrh, syntéza a hodnocení derivátů skupin léčiv s inhibiční enzymatickou aktivitou
Investor: Masaryk University
MUNI/IGA/0932/2021, interní kód MU
Name: Basic ketones and their derivatives as potential anti-infective and anti-tumor drugs
Investor: Masaryk University