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@article{2344977,
author = {Vlažná, Daniela and Krkoška, Peter and Sládečková, Michaela and Parmová, Olesja and Barusová, Tamara and Hrabcová, Karolína and Voháňka, Stanislav and Matulová, Kateřina and Adamová, Blanka},
article_location = {Lausanne},
article_number = {October 2023},
doi = {http://dx.doi.org/10.3389/fneur.2023.1258342},
keywords = {myotonic dystrophy type 2 (MD2); function tests; neuromuscular diseases (NMD); low back pain; paraspinal muscles; muscle strength; muscular endurance; respiratory muscles},
language = {eng},
issn = {1664-2295},
journal = {Frontiers in Neurology},
title = {Trunk muscle dysfunction in patients with myotonic dystrophy type 2 and its contribution to chronic low back pain},
url = {https://www.frontiersin.org/articles/10.3389/fneur.2023.1258342/full},
volume = {14},
year = {2023}
}
TY - JOUR
ID - 2344977
AU - Vlažná, Daniela - Krkoška, Peter - Sládečková, Michaela - Parmová, Olesja - Barusová, Tamara - Hrabcová, Karolína - Voháňka, Stanislav - Matulová, Kateřina - Adamová, Blanka
PY - 2023
TI - Trunk muscle dysfunction in patients with myotonic dystrophy type 2 and its contribution to chronic low back pain
JF - Frontiers in Neurology
VL - 14
IS - October 2023
SP - 1-13
EP - 1-13
PB - Frontiers
SN - 16642295
KW - myotonic dystrophy type 2 (MD2)
KW - function tests
KW - neuromuscular diseases (NMD)
KW - low back pain
KW - paraspinal muscles
KW - muscle strength
KW - muscular endurance
KW - respiratory muscles
UR - https://www.frontiersin.org/articles/10.3389/fneur.2023.1258342/full
N2 - IntroductionMyotonic dystrophy type 2 (MD2) presents with a varied manifestation. Even though the myopathy in these patients is more widespread, axial musculature involvement is one of the most prominent conditions. MD2 patients also often report chronic low back pain (CLBP). The purpose of this study was to evaluate trunk muscle function, including respiratory muscles, in patients with MD2 and to compare it with healthy controls, to determine the occurrence of CLBP in patients with MD2, and to assess whether trunk muscle dysfunction increases the risk of CLBP in these patients.MethodsWe enrolled 40 MD2 patients (age range 23 to 76 years, 26 women). A comprehensive battery of tests was used to evaluate trunk muscle function. The tests consisted of quantitative muscle strength testing of low back extensor muscles and respiratory muscles and the assessment of trunk muscle endurance. A neurological evaluation contained procedures assessing the distribution of muscle weakness, myotonia, and pain, and used questionnaires focused on these items and on disability, depression, and physical activity.ResultsThe results of this study suggest that patients with MD2 show significant dysfunction of the trunk muscles, including the respiratory muscles, expressed by decreased muscle strength and endurance. The prevalence of CLBP in patients with MD2 was 52.5%. Based on our analysis, the only independent significant risk factor for CLBP in these patients was maximal isometric lower back extensor strength in a prone position <= 15.8 kg (OR = 37.3). Other possible risk factors were severity of myotonia and reduced physical activity.ConclusionOutcomes of this study highlighted the presence of axial muscle dysfunction, respiratory muscle weakness, and frequent occurrence of CLBP together with its risk factors in patients with MD2. We believe that the findings of this study may help in management and prevention programs for patients with MD2.
ER -
VLAŽNÁ, Daniela, Peter KRKOŠKA, Michaela SLÁDEČKOVÁ, Olesja PARMOVÁ, Tamara BARUSOVÁ, Karolína HRABCOVÁ, Stanislav VOHÁŇKA, Kateřina MATULOVÁ and Blanka ADAMOVÁ. Trunk muscle dysfunction in patients with myotonic dystrophy type 2 and its contribution to chronic low back pain. \textit{Frontiers in Neurology}. Lausanne: Frontiers, 2023, vol.~14, October 2023, p.~1-13. ISSN~1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2023.1258342.
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