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@article{2345839,
author = {Muncke, Jane and Andersson, AnnaandMaria and Backhaus, Thomas and Belcher, Scott M. and Boucher, Justin M. and Almroth, Bethanie Carney and Collins, Terrence J. and Geueke, Birgit and Groh, Ksenia J. and Heindel, Jerrold J. and von Hippel, Frank A. and Legler, Juliette and Maffini, Maricel V. and Olwenn, V. Martin and Myers, John Peterson and Nadal, Angel and Nerin, Cristina and Soto, Ana M. and Trasande, Leonardo and Vandenberg, Laura N. and Wagner, Martin and Zimmermann, Lisa and Zoeller, R. Thomas and Scheringer, Martin},
article_location = {OXFORD (ENGLAND)},
article_number = {October 2023},
doi = {http://dx.doi.org/10.1016/j.envint.2023.108161},
keywords = {Food packaging; Hazard assessment; Chronic disease; Chemical safety},
language = {eng},
issn = {0160-4120},
journal = {Environment International},
title = {A vision for safer food contact materials: Public health concerns as drivers for improved testing},
url = {https://www.sciencedirect.com/science/article/pii/S0160412023004348?via%3Dihub},
volume = {180},
year = {2023}
}
TY - JOUR
ID - 2345839
AU - Muncke, Jane - Andersson, Anna-Maria - Backhaus, Thomas - Belcher, Scott M. - Boucher, Justin M. - Almroth, Bethanie Carney - Collins, Terrence J. - Geueke, Birgit - Groh, Ksenia J. - Heindel, Jerrold J. - von Hippel, Frank A. - Legler, Juliette - Maffini, Maricel V. - Olwenn, V. Martin - Myers, John Peterson - Nadal, Angel - Nerin, Cristina - Soto, Ana M. - Trasande, Leonardo - Vandenberg, Laura N. - Wagner, Martin - Zimmermann, Lisa - Zoeller, R. Thomas - Scheringer, Martin
PY - 2023
TI - A vision for safer food contact materials: Public health concerns as drivers for improved testing
JF - Environment International
VL - 180
IS - October 2023
SP - 1-18
EP - 1-18
PB - Pergamon Press
SN - 01604120
KW - Food packaging
KW - Hazard assessment
KW - Chronic disease
KW - Chemical safety
UR - https://www.sciencedirect.com/science/article/pii/S0160412023004348?via%3Dihub
N2 - Food contact materials (FCMs) and food contact articles are ubiquitous in today's globalized food system. Chemicals migrate from FCMs into foodstuffs, so called food contact chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health from hazardous FCCs because only individual substances used to make FCMs are tested and mostly only for genotoxicity while endocrine disruption and other hazard properties are disregarded. Indeed, FCMs are a known source of a wide range of hazardous chemicals, and they likely contribute to highly prevalent non-communicable diseases. FCMs can also include non-intentionally added substances (NIAS), which often are unknown and therefore not subject to risk assessment. To address these important shortcomings, we outline how the safety of FCMs may be improved by (1) testing the overall migrate, including (unknown) NIAS, of finished food contact articles, and (2) expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health. Toidentify mechanistic endpoints for testing, we group chronic health outcomes associated with chemical exposure into Six Clusters of Disease (SCOD) and we propose that finished food contact articles should be tested for their impacts on these SCOD. Research should focus on developing robust, relevant, and sensitive in-vitro assays based on mechanistic information linked to the SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics of Toxicants. Implementing this vision will improve prevention of chronic diseases that are associated with hazardous chemical exposures, including from FCMs.
ER -
MUNCKE, Jane, Anna-Maria ANDERSSON, Thomas BACKHAUS, Scott M. BELCHER, Justin M. BOUCHER, Bethanie Carney ALMROTH, Terrence J. COLLINS, Birgit GEUEKE, Ksenia J. GROH, Jerrold J. HEINDEL, Frank A. VON HIPPEL, Juliette LEGLER, Maricel V. MAFFINI, V. Martin OLWENN, John Peterson MYERS, Angel NADAL, Cristina NERIN, Ana M. SOTO, Leonardo TRASANDE, Laura N. VANDENBERG, Martin WAGNER, Lisa ZIMMERMANN, R. Thomas ZOELLER and Martin SCHERINGER. A vision for safer food contact materials: Public health concerns as drivers for improved testing. \textit{Environment International}. OXFORD (ENGLAND): Pergamon Press, 2023, vol.~180, October 2023, p.~1-18. ISSN~0160-4120. Available from: https://dx.doi.org/10.1016/j.envint.2023.108161.
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