BALLAYOVÁ, Veronika, Tereza KAUEROVÁ, Peter KOLLÁR and Oldřich FARSA. SCHIFF BASES AS POTENTIAL THERAPEUTIC AGENTS. In Student Scientific Conference MUNI Pharm. Doctoral Students 2023. 2023. ISBN 978-80-280-0324-1.
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Basic information
Original name SCHIFF BASES AS POTENTIAL THERAPEUTIC AGENTS
Authors BALLAYOVÁ, Veronika (703 Slovakia, belonging to the institution), Tereza KAUEROVÁ (203 Czech Republic, belonging to the institution), Peter KOLLÁR (203 Czech Republic, belonging to the institution) and Oldřich FARSA (203 Czech Republic, belonging to the institution).
Edition Student Scientific Conference MUNI Pharm. Doctoral Students 2023, 2023.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 30107 Medicinal chemistry
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14160/23:00132402
Organization unit Faculty of Pharmacy
ISBN 978-80-280-0324-1
Keywords in English thiosemicarbazone derivative of acetophenone; Schiff bases; metalloenzyme inhibitor; aminopeptidase N
Tags International impact
Changed by Changed by: Mgr. Daniela Černá, učo 489184. Changed: 5/4/2024 07:48.
Abstract
Schiff bases, which are carrying imine or azomethine functional group, are versatile pharmacophores capable of forming chelating complexes with various metals. Metal complexes play a crucial role in pharmaceutical sciences due to their wide and significant activities.1 Synthesized basic thiosemicarbazone and semicarbazone derivatives of acetophenone may be bioactive compounds as well. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.
Links
EF19_073/0016943, research and development projectName: Interní grantová agentura Masarykovy univerzity
MUNI/A/1682/2020, interní kód MUName: Návrh, syntéza a hodnocení derivátů skupin léčiv s inhibiční enzymatickou aktivitou
Investor: Masaryk University
MUNI/IGA/0932/2021, interní kód MUName: Basic ketones and their derivatives as potential anti-infective and anti-tumor drugs
Investor: Masaryk University
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