The aim of this article is to map the beginning of Czechoslovak-Turkish business relations from the end of the World War I until the signature of the Peace Treaty of Lausanne. It was created as a result of the work of the author, who has long been dealing with the issue of the process of the establishment of the Turkish business relations with Europe. This paper focuses mainly on the effort of the representatives of the Czechoslovak government in İstanbul to ensure an appropriate environment for the sale of Czechoslovak industrial products after the end of the World War I. The delegates of the Czechoslovak government in İstanbul considered local market as a great opportunity for the Czechoslovak firms and their products. It was nevertheless clear that, it was quite difficult task, since the beginning because several important steps were underestimated: primarily the opportunity to build on the previous business and financial cooperation of Austria — Hungary and the Ottoman Empire and initial disinterest of the Czechoslovak government. When collecting materials, the author mainly used the sources of the Ministry of Foreign Affairs of the Czech Republic and furthermore, previously published works and articles. The author is aware that the sources used for this article are far from complete.