| MASURI, Sebastiano, Maria Grazia CABIDDU, Lukáš MORÁŇ, Tereza VESSELÁ, Martin BARTOSIK, Josef HAVEL, Francesca MELONI, Enzo CADONI, Petr VAŇHARA and Tiziana PIVETTA. Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers. New Journal of Chemistry. Cambridge: ROYAL SOC. CHEMISTRY, 2023, vol. 47, No 32, p. 15125-15136. ISSN 1144-0546. Available from: https://dx.doi.org/10.1039/d3nj01317k. |
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@article{2352399,
author = {Masuri, Sebastiano and Cabiddu, Maria Grazia and Moráň, Lukáš and Vesselá, Tereza and Bartosik, Martin and Havel, Josef and Meloni, Francesca and Cadoni, Enzo and Vaňhara, Petr and Pivetta, Tiziana},
article_location = {Cambridge},
article_number = {32},
doi = {http://dx.doi.org/10.1039/d3nj01317k},
keywords = {BIOLOGICAL-ACTIVITY; CYTOTOXIC ACTIVITY; CRYSTAL-STRUCTURE; SDNA-BINDING; CELL-DEATH; CISPLATINPLATINUM; LIGANDS; SYSTEM; ACID},
language = {eng},
issn = {1144-0546},
journal = {New Journal of Chemistry},
title = {Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers},
url = {https://pubs.rsc.org/en/content/articlelanding/2023/NJ/D3NJ01317K},
volume = {47},
year = {2023}
}
TY - JOUR
ID - 2352399
AU - Masuri, Sebastiano - Cabiddu, Maria Grazia - Moráň, Lukáš - Vesselá, Tereza - Bartosik, Martin - Havel, Josef - Meloni, Francesca - Cadoni, Enzo - Vaňhara, Petr - Pivetta, Tiziana
PY - 2023
TI - Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers
JF - New Journal of Chemistry
VL - 47
IS - 32
SP - 15125-15136
EP - 15125-15136
PB - ROYAL SOC. CHEMISTRY
SN - 11440546
KW - BIOLOGICAL-ACTIVITY
KW - CYTOTOXIC ACTIVITY
KW - CRYSTAL-STRUCTURE
KW - SDNA-BINDING
KW - CELL-DEATH
KW - CISPLATINPLATINUM
KW - LIGANDS
KW - SYSTEM
KW - ACID
UR - https://pubs.rsc.org/en/content/articlelanding/2023/NJ/D3NJ01317K
N2 - We prepared six complexes with the formula [Cu(phen)(2)(Lx)](ClO4)(x: 1-6), where auxiliary ligands Lx are coumarin carboxylate derivatives bearing an oxylacetate moiety in the 6th or 7th position and different substituents in the 3rd or 4th position. Complexes show a pentacoordinated geometry around a metal ion. The possibility to complete the coordination sphere in an octahedral geometry makes the molecule able to further react. Complexes show affinity toward DNA mainly through electrostatic interactions and groove binding, while the interactions with DNA base pairs are guaranteed by the auxiliary ligands. The heteroleptic Cu(ii) complexes show cytotoxic activity in the micromolar concentration range, and mechanistic studies have shown how they can interfere at the endothelial reticulum level inducing the pro-apoptotic branch of the unfolded protein response (UPR). The actin-normalized CHOP to BiP density ratios suggest that the novel compounds induce preferentially the pro-apoptotic UPR signalling driven by the CHOP, in a dose-dependent way and according to the substituents in the coumarin moiety.
ER -
MASURI, Sebastiano, Maria Grazia CABIDDU, Lukáš MORÁŇ, Tereza VESSELÁ, Martin BARTOSIK, Josef HAVEL, Francesca MELONI, Enzo CADONI, Petr VAŇHARA and Tiziana PIVETTA. Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers. \textit{New Journal of Chemistry}. Cambridge: ROYAL SOC. CHEMISTRY, 2023, vol.~47, No~32, p.~15125-15136. ISSN~1144-0546. Available from: https://dx.doi.org/10.1039/d3nj01317k.
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