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@article{2355288, author = {Obdržálková, Marie and Ustohal, Libor and Hlavacova, Natasa and Mayerová, Michaela and Češková, Eva and Kašpárek, Tomáš and Jezova, Daniela}, article_location = {Oxford}, article_number = {10}, doi = {http://dx.doi.org/10.1016/j.heliyon.2023.e21173}, keywords = {Aldosterone; Cortisol; Non-affective psychosis}, language = {eng}, issn = {2405-8440}, journal = {Heliyon}, title = {Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study}, url = {https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub}, volume = {9}, year = {2023} }
TY - JOUR ID - 2355288 AU - Obdržálková, Marie - Ustohal, Libor - Hlavacova, Natasa - Mayerová, Michaela - Češková, Eva - Kašpárek, Tomáš - Jezova, Daniela PY - 2023 TI - Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study JF - Heliyon VL - 9 IS - 10 SP - 1-10 EP - 1-10 PB - Elsevier SN - 24058440 KW - Aldosterone KW - Cortisol KW - Non-affective psychosis UR - https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub N2 - The aim of this pilot study was to find whether the dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treat-ment outcome. Patients with the first episode of non-affective psychosis (N = 29) were examined at admission, at discharge, and at follow-up (N = 23). The biomarkers included serum aldoste-rone, cortisol, free thyroxine, thyroid stimulating hormone, and prolactin. We revealed lower baseline aldosterone and higher baseline cortisol concentrations in patients with very good outcome compared to those with good outcome after one year. We failed to reveal any significant association between treatment outcome and neurohumoral biomarkers in the whole sample at 1-year follow-up. However, baseline aldosterone concentrations negatively correlated with total PANSS scores at the discharge. Lower baseline aldosterone and higher baseline cortisol concentrations have the potential to predict a more favorable outcome for patients with the first episode of psychosis. ER -
OBDRŽÁLKOVÁ, Marie, Libor USTOHAL, Natasa HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK and Daniela JEZOVA. Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study. \textit{Heliyon}. Oxford: Elsevier, 2023, vol.~9, No~10, p.~1-10. ISSN~2405-8440. Available from: https://dx.doi.org/10.1016/j.heliyon.2023.e21173.
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