Selected neuroendocrine factors as potential molecular
biomarkers of early non-affective psychosis course in relation
to treatment outcome: A pilot study

J 2023

Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study

OBDRŽÁLKOVÁ, Marie, Libor USTOHAL, Natasa HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ et. al.

Basic information

Original name

Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study

Authors

OBDRŽÁLKOVÁ, Marie (203 Czech Republic, belonging to the institution), Libor USTOHAL (203 Czech Republic, belonging to the institution), Natasa HLAVACOVA, Michaela MAYEROVÁ (203 Czech Republic, belonging to the institution), Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Daniela JEZOVA

Edition

Heliyon, Oxford, Elsevier, 2023, 2405-8440

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30215 Psychiatry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.000 in 2022

RIV identification code

RIV/00216224:14110/23:00134686

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.heliyon.2023.e21173

UT WoS

001114112800001

Keywords in English

Aldosterone; Cortisol; Non-affective psychosis

Abstract

V originále

The aim of this pilot study was to find whether the dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treat-ment outcome. Patients with the first episode of non-affective psychosis (N = 29) were examined at admission, at discharge, and at follow-up (N = 23). The biomarkers included serum aldoste-rone, cortisol, free thyroxine, thyroid stimulating hormone, and prolactin. We revealed lower baseline aldosterone and higher baseline cortisol concentrations in patients with very good outcome compared to those with good outcome after one year. We failed to reveal any significant association between treatment outcome and neurohumoral biomarkers in the whole sample at 1-year follow-up. However, baseline aldosterone concentrations negatively correlated with total PANSS scores at the discharge. Lower baseline aldosterone and higher baseline cortisol concentrations have the potential to predict a more favorable outcome for patients with the first episode of psychosis.

Links

NU23-08-00257, research and development project

Name: Optimalizovaný longitudinální vlasový kortizol jako nástroj v diagnostice a monitorování psychiatrických poruch

Investor: Ministry of Health of the CR, Optimized longitudinal hair cortisol as a tool in diagnosis and monitoring of psychiatric disorders, Subprogram 1 - standard

Citovat

OBDRŽÁLKOVÁ, Marie, Libor USTOHAL, Natasa HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK and Daniela JEZOVA. Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study. Heliyon. Oxford: Elsevier, 2023, vol. 9, No 10, p. 1-10. ISSN 2405-8440. Available from: https://dx.doi.org/10.1016/j.heliyon.2023.e21173.

@article{2355288,
   author = {Obdržálková, Marie and Ustohal, Libor and Hlavacova, Natasa and Mayerová, Michaela and Češková, Eva and Kašpárek, Tomáš and Jezova, Daniela},
   article_location = {Oxford},
   article_number = {10},
   doi = {http://dx.doi.org/10.1016/j.heliyon.2023.e21173},
   keywords = {Aldosterone; Cortisol; Non-affective psychosis},
   language = {eng},
   issn = {2405-8440},
   journal = {Heliyon},
   title = {Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study},
   url = {https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub},
   volume = {9},
   year = {2023}
}

TY  - JOUR
ID  - 2355288
AU  - Obdržálková, Marie - Ustohal, Libor - Hlavacova, Natasa - Mayerová, Michaela - Češková, Eva - Kašpárek, Tomáš - Jezova, Daniela
PY  - 2023
TI  - Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study
JF  - Heliyon
VL  - 9
IS  - 10
SP  - 1-10
EP  - 1-10
PB  - Elsevier
SN  - 24058440
KW  - Aldosterone
KW  - Cortisol
KW  - Non-affective psychosis
UR  - https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub
N2  - The aim of this pilot study was to find whether the dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treat-ment outcome. Patients with the first episode of non-affective psychosis (N = 29) were examined at admission, at discharge, and at follow-up (N = 23). The biomarkers included serum aldoste-rone, cortisol, free thyroxine, thyroid stimulating hormone, and prolactin. We revealed lower baseline aldosterone and higher baseline cortisol concentrations in patients with very good outcome compared to those with good outcome after one year. We failed to reveal any significant association between treatment outcome and neurohumoral biomarkers in the whole sample at 1-year follow-up. However, baseline aldosterone concentrations negatively correlated with total PANSS scores at the discharge. Lower baseline aldosterone and higher baseline cortisol concentrations have the potential to predict a more favorable outcome for patients with the first episode of psychosis.
ER  -

OBDRŽÁLKOVÁ, Marie, Libor USTOHAL, Natasa HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK and Daniela JEZOVA. Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study. \textit{Heliyon}. Oxford: Elsevier, 2023, vol.~9, No~10, p.~1-10. ISSN~2405-8440. Available from: https://dx.doi.org/10.1016/j.heliyon.2023.e21173.

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