Association between polymorphism rs2421943 of the
insulin-degrading enzyme and schizophrenia: Preliminary report

J 2023

Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report

AMBROZOVÁ, Laura, Tomáš ZEMAN, Vladimír JANOUT, Jana JANOUTOVÁ, Jan LOCHMAN et. al.

Basic information

Original name

Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report

Authors

AMBROZOVÁ, Laura (703 Slovakia, belonging to the institution), Tomáš ZEMAN (203 Czech Republic, belonging to the institution), Vladimír JANOUT, Jana JANOUTOVÁ, Jan LOCHMAN (203 Czech Republic, belonging to the institution) and Omar ŠERÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Clinical Laboratory Analysis, Wiley, 2023, 0887-8013

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.700 in 2022

RIV identification code

RIV/00216224:14310/23:00134349

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1002/jcla.24949

UT WoS

001036281600001

Keywords in English

candidate gene analyses; genetic association study; insulin-degrading enzyme (IDE); miRNA; schizophrenic disorder; single nucleotide polymorphism (SNP)

Abstract

V originále

Background Insulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis. Methods We enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pathogenesis of Alzheimer's disease. The SNP was analyzed using the PCR-RFLP method. Results The G allele of the rs2421943 polymorphism was found to significantly increase the risk of developing SZ (p < 0.01) when a gender-based analysis showed that both AG and GG genotypes were associated with a more than 1.55 times increased risk of SZ in females (p < 0.03) but not in males. Besides, we identified a potential binding site at the G allele locus for has-miR-7110-5p, providing a potential mechanism for the observed association. Conclusion Our results confirm the role of the IDE gene in schizophrenia pathogenesis and suggest that future research should investigate the relationship between miRNA and estrogen influence on IDE expression in schizophrenia pathogenesis.

Links

GP309/09/P361, research and development project

Name: Vztah interakce polymorfismů kandidátních genů k patogenezi schizofrenie

Investor: Czech Science Foundation, Relationship of candidate genes polymorphisms interaction to pathogenesis of schizophrenia

Citovat

AMBROZOVÁ, Laura, Tomáš ZEMAN, Vladimír JANOUT, Jana JANOUTOVÁ, Jan LOCHMAN and Omar ŠERÝ. Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report. Journal of Clinical Laboratory Analysis. Wiley, 2023, vol. 37, 13-14, p. 1-7. ISSN 0887-8013. Available from: https://dx.doi.org/10.1002/jcla.24949.

@article{2355377,
   author = {Ambrozová, Laura and Zeman, Tomáš and Janout, Vladimír and Janoutová, Jana and Lochman, Jan and Šerý, Omar},
   article_number = {13-14},
   doi = {http://dx.doi.org/10.1002/jcla.24949},
   keywords = {candidate gene analyses; genetic association study; insulin-degrading enzyme (IDE); miRNA; schizophrenic disorder; single nucleotide polymorphism (SNP)},
   language = {eng},
   issn = {0887-8013},
   journal = {Journal of Clinical Laboratory Analysis},
   title = {Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report},
   url = {https://doi.org/10.1002/jcla.24949},
   volume = {37},
   year = {2023}
}

TY  - JOUR
ID  - 2355377
AU  - Ambrozová, Laura - Zeman, Tomáš - Janout, Vladimír - Janoutová, Jana - Lochman, Jan - Šerý, Omar
PY  - 2023
TI  - Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report
JF  - Journal of Clinical Laboratory Analysis
VL  - 37
IS  - 13-14
SP  - 1-7
EP  - 1-7
PB  - Wiley
SN  - 08878013
KW  - candidate gene analyses
KW  - genetic association study
KW  - insulin-degrading enzyme (IDE)
KW  - miRNA
KW  - schizophrenic disorder
KW  - single nucleotide polymorphism (SNP)
UR  - https://doi.org/10.1002/jcla.24949
N2  - Background Insulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis. Methods We enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pathogenesis of Alzheimer's disease. The SNP was analyzed using the PCR-RFLP method. Results The G allele of the rs2421943 polymorphism was found to significantly increase the risk of developing SZ (p < 0.01) when a gender-based analysis showed that both AG and GG genotypes were associated with a more than 1.55 times increased risk of SZ in females (p < 0.03) but not in males. Besides, we identified a potential binding site at the G allele locus for has-miR-7110-5p, providing a potential mechanism for the observed association. Conclusion Our results confirm the role of the IDE gene in schizophrenia pathogenesis and suggest that future research should investigate the relationship between miRNA and estrogen influence on IDE expression in schizophrenia pathogenesis.
ER  -

AMBROZOVÁ, Laura, Tomáš ZEMAN, Vladimír JANOUT, Jana JANOUTOVÁ, Jan LOCHMAN and Omar ŠERÝ. Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report. \textit{Journal of Clinical Laboratory Analysis}. Wiley, 2023, vol.~37, 13-14, p.~1-7. ISSN~0887-8013. Available from: https://dx.doi.org/10.1002/jcla.24949.

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