Perinatal maternal mental health and amygdala morphology in
young adulthood

J 2023

Perinatal maternal mental health and amygdala morphology in young adulthood

GUMA, Elisa, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, M. Mallar CHAKRAVARTY, Klára MAREČKOVÁ et. al.

Basic information

Original name

Perinatal maternal mental health and amygdala morphology in young adulthood

Authors

GUMA, Elisa, Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution), M. Mallar CHAKRAVARTY and Klára MAREČKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2023, 0278-5846

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.600 in 2022

RIV identification code

RIV/00216224:14740/23:00132760

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.pnpbp.2022.110676

UT WoS

000899380600008

Keywords in English

Maternal anxiety; Perinatal depression; Amygdala; Volume; Surface area

Abstract

V originále

The pre- and perinatal environment is thought to play a critical role in shaping brain development. Specifically, maternal mental health and maternal care have been shown to influence offspring brain development in regions implicated in emotional regulation such as the amygdala. In this study, we used data from a neuroimaging follow-up of a prenatal birth-cohort, the European Longitudinal Study of Pregnancy and Childhood, to investigate the impact of early postnatal maternal anxiety/co-dependence, and prenatal and early-postnatal depression and dysregulated mood on amygdala volume and morphology in young adulthood (n = 103). We observed that in typically developing young adults, greater maternal anxiety/co-dependence after birth was significantly associated with lower volume (right: t = −2.913, p = 0.0045, β = −0.523; left: t = −1.471, p = 0.144, β = −0.248) and non-significantly associated with surface area (right: t = −3.502, q = 0.069, <10%FDR, β = −0.090, left: t = −3.137, q = 0.117, <10%FDR, = −0.088) of the amygdala in young adulthood. Conversely, prenatal maternal depression and mood dysregulation in the early postnatal period was not associated with any volumetric or morphological changes in the amygdala in young adulthood. Our findings provide evidence for subtle but long-lasting alterations to amygdala morphology associated with differences in maternal anxiety/co-dependence in early development.

Links

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

NU20J-04-00022, research and development project

Name: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministry of Health of the CR, Healthy Brain Ageing in Czechia over the life-course, Subprogram 2 - junior

90062, large research infrastructures

Name: Czech-BioImaging

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

GUMA, Elisa, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, M. Mallar CHAKRAVARTY and Klára MAREČKOVÁ. Perinatal maternal mental health and amygdala morphology in young adulthood. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Elsevier, 2023, vol. 122, March, p. 1-8. ISSN 0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2022.110676.

@article{2355878,
   author = {Guma, Elisa and Andrýsková, Lenka and Brázdil, Milan and Chakravarty, M. Mallar and Marečková, Klára},
   article_number = {March},
   doi = {http://dx.doi.org/10.1016/j.pnpbp.2022.110676},
   keywords = {Maternal anxiety; Perinatal depression; Amygdala; Volume; Surface area},
   language = {eng},
   issn = {0278-5846},
   journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
   title = {Perinatal maternal mental health and amygdala morphology in young adulthood},
   url = {https://doi.org/10.1016/j.pnpbp.2022.110676},
   volume = {122},
   year = {2023}
}

TY  - JOUR
ID  - 2355878
AU  - Guma, Elisa - Andrýsková, Lenka - Brázdil, Milan - Chakravarty, M. Mallar - Marečková, Klára
PY  - 2023
TI  - Perinatal maternal mental health and amygdala morphology in young adulthood
JF  - Progress in Neuro-Psychopharmacology and Biological Psychiatry
VL  - 122
IS  - March
SP  - 1-8
EP  - 1-8
PB  - Elsevier
SN  - 02785846
KW  - Maternal anxiety
KW  - Perinatal depression
KW  - Amygdala
KW  - Volume
KW  - Surface area
UR  - https://doi.org/10.1016/j.pnpbp.2022.110676
N2  - The pre- and perinatal environment is thought to play a critical role in shaping brain development. Specifically, maternal mental health and maternal care have been shown to influence offspring brain development in regions implicated in emotional regulation such as the amygdala. In this study, we used data from a neuroimaging follow-up of a prenatal birth-cohort, the European Longitudinal Study of Pregnancy and Childhood, to investigate the impact of early postnatal maternal anxiety/co-dependence, and prenatal and early-postnatal depression and dysregulated mood on amygdala volume and morphology in young adulthood (n = 103). We observed that in typically developing young adults, greater maternal anxiety/co-dependence after birth was significantly associated with lower volume (right: t = −2.913, p = 0.0045, β = −0.523; left: t = −1.471, p = 0.144, β = −0.248) and non-significantly associated with surface area (right: t = −3.502, q = 0.069, <10%FDR, β = −0.090, left: t = −3.137, q = 0.117, <10%FDR, = −0.088) of the amygdala in young adulthood. Conversely, prenatal maternal depression and mood dysregulation in the early postnatal period was not associated with any volumetric or morphological changes in the amygdala in young adulthood. Our findings provide evidence for subtle but long-lasting alterations to amygdala morphology associated with differences in maternal anxiety/co-dependence in early development.
ER  -

GUMA, Elisa, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, M. Mallar CHAKRAVARTY and Klára MAREČKOVÁ. Perinatal maternal mental health and amygdala morphology in young adulthood. \textit{Progress in Neuro-Psychopharmacology and Biological Psychiatry}. Elsevier, 2023, vol.~122, March, p.~1-8. ISSN~0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2022.110676.

Detailed Information on Publication Record