A complex role of Arabidopsis CDKD;3 in meiotic progression and
cytokinesis

J 2023

A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis

TANASA, Sorin, Neha SHUKLA, Albert CAIRO CALZADA, Sri Ranjani GANJI, Pavlína MIKULKOVÁ et. al.

Basic information

Original name

A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis

Authors

TANASA, Sorin (642 Romania, belonging to the institution), Neha SHUKLA (356 India, belonging to the institution), Albert CAIRO CALZADA (724 Spain, belonging to the institution), Sri Ranjani GANJI (356 India, belonging to the institution), Pavlína MIKULKOVÁ (203 Czech Republic, belonging to the institution), Soňa VALUCHOVÁ (703 Slovakia, belonging to the institution), Vivek Kumar RAXWAL (356 India, belonging to the institution), Claudio CAPITAO, Arp SCHNITTGER, Zbyněk ZDRÁHAL (203 Czech Republic, belonging to the institution) and Karel ŘÍHA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Plant Direct, Wiley, 2023, 2475-4455

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10611 Plant sciences, botany

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.000 in 2022

RIV identification code

RIV/00216224:14740/23:00132765

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1002/pld3.477

UT WoS

000943734000001

Keywords in English

Arabidopsis thaliana; cell cycle; cyclin dependent kinase; cytokinesis; meiosis

Abstract

V originále

Meiosis is a specialized cell division that halves the number of chromosomes in two consecutive rounds of chromosome segregation. In angiosperm plants is meiosis followed by mitotic divisions to form rudimentary haploid gametophytes. In Arabidopsis, termination of meiosis and transition to gametophytic development are governed by TDM1 and SMG7 that mediate inhibition of translation. Mutants deficient in this mechanism do not form tetrads but instead undergo multiple cycles of aberrant nuclear divisions that are likely caused by the failure to downregulate cyclin dependent kinases during meiotic exit. A suppressor screen to identify genes that contribute to meiotic exit uncovered a mutation in cyclin-dependent kinase D;3 (CDKD;3) that alleviates meiotic defects in smg7 deficient plants. The CDKD;3 deficiency prevents aberrant meiotic divisions observed in smg7 mutants or delays their onset after initiation of cytokinesis, which permits formation of functional microspores. Although CDKD;3 acts as an activator of cyclin-dependent kinase A;1 (CDKA;1), the main cyclin dependent kinase that regulates meiosis, cdkd;3 mutation appears to promote meiotic exit independently of CDKA;1. Furthermore, analysis of CDKD;3 interactome revealed enrichment for proteins implicated in cytokinesis, suggesting a more complex function of CDKD;3 in cell cycle regulation.

Links

EF15_003/0000479, research and development project

Name: Regulace rostlinné meiózy

GC21-25163J, research and development project

Name: Funkce a dynamika telomér v rostlinné meióze

Investor: Czech Science Foundation, A means to the ends - analysis of telomere function and dynamics in plant meiosis

LM2018127, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

90127, large research infrastructures

Name: CIISB II

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

TANASA, Sorin, Neha SHUKLA, Albert CAIRO CALZADA, Sri Ranjani GANJI, Pavlína MIKULKOVÁ, Soňa VALUCHOVÁ, Vivek Kumar RAXWAL, Claudio CAPITAO, Arp SCHNITTGER, Zbyněk ZDRÁHAL and Karel ŘÍHA. A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis. Plant Direct. Wiley, 2023, vol. 7, No 3, p. 1-16. ISSN 2475-4455. Available from: https://dx.doi.org/10.1002/pld3.477.

@article{2355903,
   author = {Tanasa, Sorin and Shukla, Neha and Cairo Calzada, Albert and Ganji, Sri Ranjani and Mikulková, Pavlína and Valuchová, Soňa and Raxwal, Vivek Kumar and Capitao, Claudio and Schnittger, Arp and Zdráhal, Zbyněk and Říha, Karel},
   article_number = {3},
   doi = {http://dx.doi.org/10.1002/pld3.477},
   keywords = {Arabidopsis thaliana; cell cycle; cyclin dependent kinase; cytokinesis; meiosis},
   language = {eng},
   issn = {2475-4455},
   journal = {Plant Direct},
   title = {A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis},
   url = {https://doi.org/10.1002/pld3.477},
   volume = {7},
   year = {2023}
}

TY  - JOUR
ID  - 2355903
AU  - Tanasa, Sorin - Shukla, Neha - Cairo Calzada, Albert - Ganji, Sri Ranjani - Mikulková, Pavlína - Valuchová, Soňa - Raxwal, Vivek Kumar - Capitao, Claudio - Schnittger, Arp - Zdráhal, Zbyněk - Říha, Karel
PY  - 2023
TI  - A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis
JF  - Plant Direct
VL  - 7
IS  - 3
SP  - 1-16
EP  - 1-16
PB  - Wiley
SN  - 24754455
KW  - Arabidopsis thaliana
KW  - cell cycle
KW  - cyclin dependent kinase
KW  - cytokinesis
KW  - meiosis
UR  - https://doi.org/10.1002/pld3.477
N2  - Meiosis is a specialized cell division that halves the number of chromosomes in two consecutive rounds of chromosome segregation. In angiosperm plants is meiosis followed by mitotic divisions to form rudimentary haploid gametophytes. In Arabidopsis, termination of meiosis and transition to gametophytic development are governed by TDM1 and SMG7 that mediate inhibition of translation. Mutants deficient in this mechanism do not form tetrads but instead undergo multiple cycles of aberrant nuclear divisions that are likely caused by the failure to downregulate cyclin dependent kinases during meiotic exit. A suppressor screen to identify genes that contribute to meiotic exit uncovered a mutation in cyclin-dependent kinase D;3 (CDKD;3) that alleviates meiotic defects in smg7 deficient plants. The CDKD;3 deficiency prevents aberrant meiotic divisions observed in smg7 mutants or delays their onset after initiation of cytokinesis, which permits formation of functional microspores. Although CDKD;3 acts as an activator of cyclin-dependent kinase A;1 (CDKA;1), the main cyclin dependent kinase that regulates meiosis, cdkd;3 mutation appears to promote meiotic exit independently of CDKA;1. Furthermore, analysis of CDKD;3 interactome revealed enrichment for proteins implicated in cytokinesis, suggesting a more complex function of CDKD;3 in cell cycle regulation.
ER  -

TANASA, Sorin, Neha SHUKLA, Albert CAIRO CALZADA, Sri Ranjani GANJI, Pavlína MIKULKOVÁ, Soňa VALUCHOVÁ, Vivek Kumar RAXWAL, Claudio CAPITAO, Arp SCHNITTGER, Zbyněk ZDRÁHAL and Karel ŘÍHA. A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis. \textit{Plant Direct}. Wiley, 2023, vol.~7, No~3, p.~1-16. ISSN~2475-4455. Available from: https://dx.doi.org/10.1002/pld3.477.

Detailed Information on Publication Record